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Abstract
Bilayered tablets containing Dasatinib SR and dasatinib IR were successfully prepared by direct compression and wet granulation method respectively. The physiochemical evaluation results for the granules of all trials pass the official limits in angle of repose, compressibility index. The physiochemical evaluation results for the dry blend of all trials pass the official limits in angle of repose, compressibility index. The prepared blend for IR relaese were also maintained the physiochemical properties of tablets such as thickness, hardness, weight variation, friability. The optimized formulation contains the average thickness of 2.58±0.66, average hardness of 4.6±0.57, average weight of 183±1.14, friability of 0.34and 100.24±1.25%. The prepared dry mixer for sustained release were also maintained the physiochemical properties of tablets such as thickness, hardness, weight variation, friability. The optimized formulation contains the average thickness of 3.80±0.80, average hardness of 7.6±0.40, average weight of 178±0.54, friability of 0.36. In the F3 trial, the optimized formulation was F3 trial which releasesthe dasatinib in sustained manner in 1st hour it releases 28 % but the remaining drug release was sustained up to 12 hours and dasatinib immediate release with in a 20min since the tablet disintegrated within 2 minutes 12 seconds.