Main Article Content
Abstract
The present study outlines a systematic approach for designing and development of Terbutaline floating tablets to enhance the bioavailability and therapeutic efficacy of the drug. Floating tablets of Terbutaline have shown sustained release there by proper duration of action at a particular site and are designed to prolong the gastric residence time after oral administration. Different formulations were formulated by using direct compression method. A floating drug delivery system (FDDS) was developed by using sodium bicarbonate as gas-forming agent and HPMC E5, Eudragit RLPO and Sodium carboxy methylcellulose as polymers. The prepared tablets were evaluated in terms of their physical characteristics, precompression parameters, in vitro release and buoyancy lag time. The results of the in vitro release studies showed that the optimized formulation (T7) could sustain drug release for 12 hrs by using Sodium carboxy methylcellulose in the concentration of 5mg. The in vitro drug release followed zero order kinetics.