Main Article Content
Abstract
Orally disintegrating tablets (ODTs) quickly break down or dissolve in the mouth without the need for water. The demand for orally disintegrating tablets (ODTs) has experienced a significant surge, leading to a substantial expansion of this field within the pharmaceutical business and academics. Orally dissolving tablets are becoming increasingly popular compared to regular tablets since they are convenient to administer and suitable for patients. This study aims to create orally disintegrating tablets of Quetiapine fumarate (QTP). The tablets were formulated using a novel technique called co-processed super disintegrates technology. The preparations were made using the direct compression approach. The optimal flow properties, such as angle of repose, bulk density, and tapped density, were demonstrated by the amalgamation of all the formulations. The produced tablets exhibited favorable post-compression characteristics and successfully met all quality control evaluation criteria according to the I.P limits. The QF4 formulation exhibited the highest drug release, specifically 99.21%, within a 30-minute timeframe. Therefore, it is regarded as the optimum formulation. The QF4 formulation includes second control point (CP2) as a highly effective disintegrant at a strength of 10 mg. The second control point (CP 2) consists of a mixture of CCS and CP in a ratio of 1:2. The current investigation showcased the capacity for swift assimilation, enhanced availability for the body to utilize, successful treatment outcomes, and adherence from patients. The rapid beginning of action and improved anti-psychiatric activity of QTP were observed in fast dissolving tablets made by utilizing combined super disintegrates technology of QTP.