Main Article Content


In current scenario oral drug delivery has been notorious for decades as the most widely utilized route of administration among all the routes that have been explode for systematic delivery of drug via various pharmaceutical products of different dosage form. And hence only, aim of the present study was to formulate and evaluate a bilayer matrix tablet containing Ramipril as immediate release and Metformin as sustained release. Ramipril was formulated as fast dissolving layer using sodium starch glycolate, crospovidone, croscarmellose sodium as superdisintegrants in different concentration and Metformin as sustained release layer using matrix forming material like HPMC, Guargum, xanthum, Eudragit. Ramipril fast dissolving layer and metformin sustained release layer was prepared by direct compression method and wet granulation method  and prepared layer were evaluated for hardness, thickness, weight variation, friability, drug content, in vitro disintegration time(not for metformin layer) and in vitro drug release study as described in chapter-4. The in vitro release of Ramipril from formulated fast dissolving layer was rapid. Consequently bilayer tablets of Ramipril and Metformin as fast and sustained release combination could be used to improve patient compliance towards the effective management of diabetes along with diabetic hypertension and nephropathic diseases.


Ramipril Bilayer tablets metformin Iimmediate and Sustain release

Article Details