Main Article Content
Abstract
This dissertation work was done with an aim to design porous tablets of Lovastatin and evaluation of the tablets for various parameters including in vitro drug release studies. Lovastatin tablets were formulated by using microcrystalline cellulose as filler, camphor and menthol as subliming agents, crospovidone and CCS and sodium starch glycolate as super disintegrant and magnesium stearate as lubricant. The powdered blend were compressed into tablets and were analyzed for the parameters such as average weight, disintegration time, friability, thickness, weight variation, hardness, and drug content. The formulation F6 is formulated by using subliming agent and super disintegrant where it can ensure burst release of the drug so that the release cannot be interlinked. The formulation F6 containing 10% of menthol showed disintegration time of less than 1min after drying. Menthol as subliming agent was found to be most effective of all other subliming agents as it had showed drastic effect on the drug release. All other parameters viz: Hardness, Thickness, Weight variation and drug content were also found to be within limits. The disintegration time and drug content of the tablets were found to be satisfactory even after subjecting the tablets to stability studies at 40oC and 75%RH for 1 month and 3 months respectively.