Main Article Content

Abstract

The Bilayered tablets containing Metformin SR and Rosuvastatin IR were successfully prepared by direct compression method and wet granulation method respectively. Various formulations were prepared and evaluated with an aim of presenting Metformin as sustained release and Rosuvastatin as immediate release for improving the patient’s compliance. The physiochemical evaluation results for the granules of all trials pass the official limits in angle of repose, compressibility index. The prepared blend for IR layer tablets and SR layer tablets were also maintained the physiochemical properties of tablets such as thickness, hardness, weight variation, friability. The optimized formulation F5 in IR formulations contains the average thickness of 2.98mm, average hardness of 5.9 kg/cm2, average weight of 152mg, friability of 0.36%.  The optimized formulation F4b in SR formulations contains the average thickness of 5.9 mm, average hardness of 8.4 kg/cm2, friability of 0.30%.The F4b formulation which releases the Metformin in sustained manner in 1st hour it releases 26.58% but the remaining drug release was sustained up to 12 hours and Rosuvastatin immediate release F5 formulation showed 100.61 % drug release within 60 min. With the data of kinetic analysis, F4b formulation showed best linearity in Higuchi’s Equation plot indicating that the release of drug from matrix tablet follows Non Fickiandiffusion.The dissolution study was carried out for optimized bilayer tablet and it correlates with the drug release of individual release layer formulations.

Keywords

Direct Compression Method Wet Granulation Method

Article Details