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The aim of the present work is to Formulate and Evaluate controlled release of Acyclovir matrix tablets used for treatment of viral infections.  Development of SR Acyclovir is proposed considering the adverse event profile and high fluctuation index of Acyclovir observed with SR dosage forms. In the present work, attempts were made to formulate and evaluate controlled release of matrix tablets of Acyclovir.  Acyclovir was subjected to preformulation studies, based on the results obtained Acyclovir controlled release tablets were successfully formulated. Formulations prepared by direct compression technique using sodium alginate and xanthan gum as control release polymers. Set of trials were formulated for which Acyclovir evaluated parameters (bulk density, tapped density, compressibility index, hausner’s ratio, weight, thickness, hardness) were found to lie within the specifications Dissolution study was performed in USP type II apparatus at 100 RPM in 0.1 HCL for 2 hours followed by pH 1.2 and pH 6. 8 phosphate buffer.  From the results of the invitro study it appears that the release of the Acyclovir was significantly influenced by the characteristics of the polymer used.



Acyclovir, Polymers, Direct compression technique, in vitro drug release studies, Zero order kinetics.

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