Main Article Content
Abstract
The present work was designed to formulate Metoprolol Succinate microspheres by using ethyl cellulose polymer by solvent evaporation method and by using sodium alginate by ion gelation method and comaprision was made and evaluated that solvent evaporation method proves to be best method than ion gelation method. Preformulation studies were done for bulk drugs. The MetoprololSuccinate microspheres were formulated and evaluated. The formulation F3 has the highest entrapment efficiency. The drug loading was found to decrease with increase in the amount of polymer related to drug. The particle size of a microsphere was determined by optical microscopy and all the batches of microspheres show uniform size distribution. The particle size was found to be in the range of 39.72 to 57.26 µm. The prepared microspheres had good spherical geometry with smooth surface as evidenced by the scanning electron microscopy. The invitro dissolution studies that the MetoprololSuccinate microspheres formulation F3 showed better controlled release over a period of 12hrs than the other formulations.It was concluded that as the polymer concentration increases, density of polymer increases that results in increased diffusion path length, which the drug molecules have to traverse so, the drug release of F3 formulation takes long time than other formulations. For all the formulations dissolution profile graph and percentage of drug release Vs time was plotted. From all the parameters mentioned above were taken, including surface characteristics of the formulation, drug polymer ratio and time F3 Shows the reliable results.