Main Article Content
Abstract
In the present work, mucoadhesive microspheres of valacyclovir using Sodium alginate along with Carbopol 934 and HPMC K100 as copolymers were formulated to deliver valacyclovir via oral route. The results of this investigation indicate that Ionotropic gelation method can be successfully employed to fabricate valacyclovir microspheres. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymer used. Analysis of drug release mechanism showed that the drug release from the formulations followed the best fit higuchi’s model of drug release diffusion mechanism and follows zero oreder kinectics. Based on the results of evaluation tests formulation coded VM3 was concluded as best formulation.