Journal of Pharmacreations

Analysis Of Anti T.B Drugs For Developed Rp- Hplc Method By Validation Parameters As Per Ich Guidelines

J. Madhavi Latha, R. Kishore, D. Jeevan Mani Babu, D. Supriya — Wed, 05 Mar 2025 00:00:00 +0000

This covers the separation principle, various stationary and mobile phase types, and separation-affecting variables. This article highlights the need of developing and testing such methods in addition to outlining the advantages of using RP-HPLC in industries like pharmaceutical, food, and environmental analysis. As examples of more recent advancements in RP-HPLC, new stationary and mobile phases, RP-HPLC downsizing, and hyphenated methods are also discussed. This review article provides a comprehensive tool for designing, refining, and validating RP-HPLC processes.

Validation Parameters Using Rp – Hplc Method For The Simultaneous Determination Of Emtricitabine And Tenofovir Disoproxil Fumarate

D. Jeevan Mani Babu, M. Sireesha, J. Madhavi Latha, T. Aswini — Wed, 05 Mar 2025 00:00:00 +0000

Separation of Emtricitabine was successfully achieved Dona:YMC PACK PRO 150X4.6mm, 5µm, C18 or equivalenting an isocratic mode utilizing KH2PO4: Methanol(65:35) at a flowrate of 1.0mL/mins and eluate was monitored at 265nm, with a retention time of 3.150 minutes for Emtricitabine respectively. Assay Results 98.82%The specificity of the method shows good correlation between retention times of standard with the sample so, the method specifically determines the analyte in the sample without interference from excipients of tablet dosage forms. The method was extensively validated according to ICH guidelines for Assay.

A Review on Transdermal Drug Delivery System

Mon, 10 Mar 2025 00:00:00 +0000

As an alternative to traditional needle injections, a number of non-invasive administrations have recently surfaced. Among these, a transdermal drug delivery system (TDDS) is the most appealing due to its low rejection rate, exceptional ease of administration, and exceptional patient convenience and persistence. In addition to the pharmaceutical industry, TDDS may find use in the skin care sector, which includes cosmetics. This approach can avoid local drug concentration accumulation and nonspecific drug delivery to tissues that are not the drug's target because it primarily uses local administration. Nevertheless, the physicochemical characteristics of the skin result in a number of barriers and limitations in transdermal delivery, and a great deal of research has been done to address these issues. We outline the various TDDS method types that are currently available in this review, as well as critically discuss each method's unique benefits and drawbacks, characterization techniques, and potential. Advances in the study of these substitute techniques have demonstrated the high efficiency that TDDS possesses, which is anticipated to find use in a variety of domains.

Synthesis and biological evaluation of phenothiazine derivatives

Mon, 17 Mar 2025 00:00:00 +0000

Phenothiazine derivatives have been synthesized and evaluated for their biological activities. A series of phenothiazine derivatives were synthesized using a facile and efficient method, and their structures were confirmed by spectroscopic analysis. The synthesized compounds were evaluated for their antimicrobial, antioxidant, and cytotoxic activities. The results showed that some of the synthesized compounds exhibited significant antimicrobial and antioxidant activities, while others showed promising cytotoxic activity against certain cancer cell lines. The structure-activity relationship (SAR) studies revealed that the presence of certain functional groups on the phenothiazine ring played a crucial role in determining the biological activities of the compounds. These findings suggest that phenothiazine derivatives could be potential lead compounds for the development of new drugs against various diseases.