Journal of Pharmacreations

Formulation and in vitro evaluation of controlled release matrix tablets of metoprolol

Jarupula Sunitha, B. Manjula , K. Balaji — Tue, 08 Oct 2024 00:00:00 +0000

The present study involves in the formulation and evaluation of Controlled release tablets of Metoprolol (25mg). The objective of the present study was to formulate Metoprolol Controlled release tablets by direct compression method by using Eudragit S 100, HPMC K4 M and HPMC K15 M. MCC was used as diluting agent, Magnesium stearate was used as a lubricant and Talc was used as a glident. This Controlled release the drug up to 12 hours in predetermined rate. The formulated powder blend was evaluated for bulk density, tapped density, compressibility index and angle of repose. The formulated tablets were evaluated for physical characteristics of Controlled release tablets such as thickness, hardness, friability, weight variation and drug content. The results of the formulations found to be within the limits specified in official books. The tablets were evaluated for In-vitro drug release studies by using USP type II dissolution test apparatus. The dissolution test was performed in 0.1 N HCL for 2 hr and phosphate buffer pH 6.8 for 12hrs. The in-vitro cumulative drug release profile of all formulations F1-F12 hours showed good drug release. Hence, Formulation F7 was the most promising formulation as it gives satisfactory release (98.29 %) for 12 hours and F7 found to be the best formulation.

Formulation and evaluation of oral controlled release tablets Of nifedipine

Bodineni Sudheer Kumar Babu, M. Rama Krishna, K. Balaji — Tue, 08 Oct 2024 00:00:00 +0000

The aim of the present study was to develop controlled release formulation of Nifedipine to maintain constant therapeutic levels of the drug for over 12 hrs. Karaya gum, Acacia and Tragacanth were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. From the dissolution studies it was evident that the formulation (F4) showed better and desired drug release pattern i.e., 98.14 % in 12 hours. It contains the Acacia polymer. It followed Zero order release kinetics mechanism.

Trends In Granulation Techniques

Fri, 11 Oct 2024 00:00:00 +0000

Granulation is a crucial process in pharmaceutical production, specifically in the manufacturing of tablets and capsules. It involves enlarging particles through agglomeration to create free- flowing, dust-free granules that are easy to compress. However, granulation presents various challenges due to the high quality standards required for the granules in terms of uniformity, size, density, hardness, moisture content, compressibility, and stability. There are two main types of granulation processes: wet granulation, which involves the use of liquid, and dry granulation, which does not require liquid. Choosing the appropriate process depends on understanding the physicochemical properties of the drug, excipients, desired flow and release characteristics, among others. Various technologies such as spray drying, roller compaction, high shear mixing, and fluid bed granulation are commonly used in granulation. The field of pharmaceutical granulation technology is continuously evolving, with new and innovative technologies emerging. This review highlights recent advancements in granulation techniques and technologies, including pneumatic dry granulation, reverse wet granulation, steam granulation, moisture-activated dry granulation, thermal adhesion granulation, freeze granulation, and foamed binder or foam granulation, providing a brief description of each development along with its significance and limitations.

Formulation and Evaluation of Topiramate Immediate Release Tablets

B. Manusri, A. Madhusudhan Reddy — Sat, 12 Oct 2024 00:00:00 +0000

The aim of the present study is to develop and evaluate the immediate release tablet of Topiramate by direct compression method. The super disintegrant Khaya gum, Kyron T-314 and Poloxomer 188were used for immediate release of drug from tablet. The precompression blends of Topiramate were characterized with respect to angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio. The precompression blend of all the batches indicates good to fair flowability, compressibility and were compressed into tablets. The formulated tablets were evaluated for various quality control parameters. The pure drug and super disintegrant formulations were subjected to FTIR studies, the results were showed that there is no interaction between the drug and excipients. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F3 exhibits highest dissolution using Kyron T-314 showed faster drug release 98.51%.

Formulation and Evaluation of Paliperidone Sustained Release Tablets

E. Menaka, B. Sandeep , K. Usha — Sun, 20 Oct 2024 00:00:00 +0000

In the present work, an attempt has been made to develop Sustained release tablets of Paliperidone by selecting different types of Sodium alginate, Chitosan and HPMC K 15 M as retarding polymers. All the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F5 formulation showed maximum % drug release i.e., 99.68 % in 12 hours. hence it is considered as optimized formulation F5 which contains Chitosan (12 mg). Optimized formulation F5 was followed Zero order release mechanism.

Current Regulations For Biological Products

M. Sai Teja, B. Sandeep , Ch. Sunitha — Sun, 20 Oct 2024 00:00:00 +0000

Quality control (QC) is a procedure or set of procedures intended to ensure that a manufactured product or performed service adheres to a defined set of quality criteria or meets the requirements of the client or customer. QC is similar to, but not identical with, quality assurance (QA). There are various quality control parameters and guidelines which ensure us to deliver a slandered and contamination free product in the market. These quality control procedure and guidelines ensure the product development in the global slandered. In past years the role of quality control is increased in pharmaceutical and biotechnology industry. The maintenance of product quality is maintained by these procedure and guideline. Here we give a analytical description about why quality control procedures are important in the field of pharmaceutical and biological product manufacturing and what are the similarity between these procedures in both industries.

Current Trends in Review of CTD Dossiers

E. Swarnalatha, L. Harikiran — Sun, 20 Oct 2024 00:00:00 +0000

A Validated Rp-Hplc Method For The Simultaneous Estimation Of Ciprofloxacin And Fluocinolone In Bulk Form And Pharmaceutical Dosage Forms

M. Anusha, Ch. Sunitha, L. Harikiran — Sun, 20 Oct 2024 00:00:00 +0000

Formulation And In-Vitro Evaluation Of Eprosartan Gelispheres

Poojari Ravali, Dr.J. Ramesh — Sun, 20 Oct 2024 00:00:00 +0000

Eprosartan is an antihistamine agent used for the symptomatic relief of seasonal allergic rhinitis such as sneezing, rhinorrhea, pruritus, lacrimation, and nasal congestion. The aim of present research is to develop Eprosartan gelispheres by using ionic gelation method. Eprosartan gelispheres were prepared using different ratios of polymers with alone and combination like HPMC K15M, Ethyl cellulose and carbapol as 1:1, 1:1.5, 1:2 Eprosartan gelispheres were evaluated for percentage yield, particle size. Surface morphology, flow properties, drug content and entrapment efficiency and were found to be within the acceptable range. Invitro dissolution studies of the gelispheres revealed that the formulation F9 containing drug and polymer ratio of Drug: carbapol, in 1:2. shows maximum drug release at the end of 12 hours, when compared with the other formulations. Drug release kinetics of the optimized formulation states that the formulation F9 follows zero order drug release with fickian diffusion mechanism.

Formulation And Evaluation Of Mesalazine Solid Dispersion Loaded Suppositories

SK. Musharraf , Aukunuru Jitha — Sun, 20 Oct 2024 00:00:00 +0000

Methodology Development To Synthesis, Characterisation Of Flavone Derivatives And Their Anticancer Activity

K. Alekhya, K. Sundeep — Sun, 20 Oct 2024 00:00:00 +0000

Flavone derivatives have garnered significant interest in medicinal chemistry due to their promising anticancer properties. This study focuses on the development of an efficient and reproducible methodology for the synthesis and characterization of flavone derivatives. A systematic approach was employed, integrating modern synthetic techniques to achieve high yield and purity of the derivatives. Comprehensive characterization was performed using spectroscopic methods, including NMR, FTIR, and Mass Spectrometry, to confirm structural integrity and molecular composition. The anticancer activity of the synthesized compounds was evaluated through in vitro cytotoxicity assays on various cancer cell lines, highlighting their potential as chemotherapeutic agents. Notable findings include specific derivatives exhibiting significant cytotoxicity with IC50 values comparable to standard anticancer drugs. The structure-activity relationship (SAR) analysis revealed key functional groups contributing to enhanced efficacy. This research lays the groundwork for future studies on flavone derivatives as novel anticancer agents and their translation into clinical applications.

Development And Validation Of Analytical Method For Simultaneous Estimation Of Econazole And Triamcinolone By Rp- Hplc

Bokka Sruthi, Adapa. Venkateswara Rao, B. Deekshi Gladiola — Sun, 24 Nov 2024 00:00:00 +0000

Formulation And Evaluation Of Haloperidol Fast Dissolving Tablets

Kadimi Devi Sravani, B. Deekshi Gladiola, Buddha Sravana Sree — Sun, 24 Nov 2024 00:00:00 +0000

The demand for fast dissolving tablets has been growing during the last decade . especially for elderly children who have swallowing difficulties. In the present work fast dissolving tablets of Haloperidol were prepared Sodium croscarmellose, Crospovidone and Sodium starch glycolate as super disintegrants by the direct compression method. The tablets prepared were evaluated for various parameters including weight variation, hardness, friability, in vitro drug release and drug content are within the limits as per IP limits. Fats dissolving tablets of Haloperidol have enhanced dissolution and will lead to improved bioavailability and more effective therapy.

Formulation Development And In Vitro Evaluation Of Oral Dissolving Films Containing Palonosetron

Guttula Leela Madhuri, B. Deekshi Gladiola, T.K.V. Kesava Rao — Sun, 24 Nov 2024 00:00:00 +0000

Palonosetron is an 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is used for the control of delayed CINV—nausea and vomiting and there are tentative data to suggest that it may be more effective than granisetron. Present work aimed at preparing quick onset of action which is beneficial in hypertension, aiding in the enhancement of bioavailabity and is very convenient for administration without the problem of swallowing and using water. The film were prepared by using polymers such asPolyvinyl alcohol, Maltodextrin and Propylene glycol by a solvent casting method. They were evaluated for physical characteristics such as Thickness, Weight Variation, Disintegration time, Drug content, Tensile strength, % Elongation, Folding Endurance and Invitro Dissolution Studies give satisfactory results. The in vitro dissolution time of the optimized batch F4 was found to be 98.97%. The optimized batch in vitro disintegration time was found to 14 sec.

Analytical method development and validation for the simultaneous estimation of azelnidipine and telmisartan by RP-HPLC In bulk and tablet dosage forms.

Geddam Divya, Adapa. Venkateswara Rao, T.K.V. Kesava Rao — Sun, 24 Nov 2024 00:00:00 +0000

A new, simple, rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validation of Azelnidipine and Telmisartan in its pure form as well as in combined marketed formulation. Chromatography was carried out on a Phenomenex Luna C18 (4.6mm×250mm) 5µm particle size column using a mixture of Methanol: Phosphate Buffer (pH-4.2) (37:63% v/v) as the mobile phase at a flow rate of 1.0ml/min, thedetection was carried out at 260 nm. The retention time of the Azelnidipine and Telmisartan was found to be was 2.133, 3.692±0.02 min respectively. The method was validated according to ICH guidelines for linearity, sensitivity, accuracy, precision, specificity and robustness. The method produce linear responses in the concentration range of 20-60mg/ml of Azelnidipine and 10-30mg/ml of Telmisartan.The inter-day and intra-day precisions were found to be within limits. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.