Journal of Pharmacreations https://pharmacreations.com/jpc en-US editorpharmacreations@gmail.com (Dr.N.Sriram) editorpharmacreations@gmail.com (Dr.N.Sriram) Tue, 26 Jul 2022 15:08:14 +0000 OJS 3.2.1.4 http://blogs.law.harvard.edu/tech/rss 60 Analytical method development and validation for the simultaneous estimation of axitinib by using RP-HPLC technique https://pharmacreations.com/jpc/article/view/243 <p>A simple and selective LC method is described for the determination of AXITINIB dosage forms. Chromatographic separation was achieved on a c<sub>18 </sub>column using mobile phase consisting of a mixture of Triethylamine Buffer: Acetonitrile (50:50) with detection of 254nm. Linearity was observed in the range 15-45 µg /ml for AXITINIB (r<sup>2</sup> =0.997) for the amount of drug estimated by the proposed methods was in good agreement with the label claim. The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.</p> Mahesh Avula, S. Mahesh, Manasa Mangali, K. Maneesha Reddy, E. Manjula, Srilakshmi Copyright (c) 2022 https://pharmacreations.com/jpc/article/view/243 Tue, 26 Jul 2022 00:00:00 +0000 Analytical method development and validation for the simultaneous estimation of doxepin by using rp-hplc technique https://pharmacreations.com/jpc/article/view/244 <p>A simple and selective LC method is described for the determination of Doxepin dosage forms. Chromatographic separation was achieved on a c<sub>18 </sub>column using mobile phase consisting of a mixture of Triethyl amine: ACN (60:40v/v/v), with detection of 250 nm. Linearity was observed in the range 75-150 µg /ml for Doxepin(r<sup>2</sup> =0.999) for drugs estimated by the proposed methods was in good agreement with the label claim quality control department in industries, approved testing laboratories, bio-pharmaceutical and bio-equivalence studies and in clinical pharmacokinetic studies in near future.</p> P. Sateesh, G. Sujitha, Qadeer, S. Sandeep Kumar, Meghavath Manjula, Shankar Copyright (c) 2022 https://pharmacreations.com/jpc/article/view/244 Tue, 26 Jul 2022 00:00:00 +0000 Analytical method development and validation for the simultaneous estimation of canagliflozin by using rp-hplc technique https://pharmacreations.com/jpc/article/view/245 <p>A simple and selective LC method is described for the determination of CANAGLIFLOZIN dosage forms. Chromatographic separation was achieved on a c<sub>18 </sub>column using mobile phase consisting of a mixture of Methanol:ACN:H<sub>2</sub>O (30:50:20v/v/v), with detection of 250 nm. Linearity was observed in the range 20-60 µg /ml for CANAGLIFLOZIN(r<sup>2</sup> =0.999) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim. The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2.</p> N. Bhavitha Reddy, Divya Kondakindi, B. Divya, S. Drakshayani, Hari prasad Reddy, B. Sreedevi Copyright (c) 2022 https://pharmacreations.com/jpc/article/view/245 Tue, 26 Jul 2022 00:00:00 +0000 Analytical method development and validation for the simultaneous estimation of atomoxetine hydrochloride by using rp-hplc technique https://pharmacreations.com/jpc/article/view/246 <p>The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form. It can be effectively applied for routine analysis in research institutions, quality control department in meant in industries, approved testing laboratories studies in near future.</p> CH. Sai Teja, M. Sandeep, L. Shekar, Sheshagiri Palthi, P. Shireesha, Beaula Rani Copyright (c) 2022 https://pharmacreations.com/jpc/article/view/246 Tue, 26 Jul 2022 00:00:00 +0000 Effect of pcod (polycystic ovarian disorder) on infertility https://pharmacreations.com/jpc/article/view/247 <p>While many women with polycystic ovary syndrome (PCOS) are overweight, obese or centrally obese, the effect of excess weight on the outcomes of PCOS is inconsistent. The review aimed to assess the effects of overweight, obesity and central obesity on the reproductive, metabolic and psychological features of PCOS. MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL) and PSYCINFO were searched for studies reporting outcomes according to body mass index categories or body fat distribution. Data were presented as mean difference or risk ratio (95% confidence interval). This review included 30 eligible studies. Overweight or obese women with PCOS had decreased sex hormone-binding globulin (SHBG), increased total testosterone, free androgen index, hirsutism, fasting glucose, fasting insulin, homeostatic model assessment-insulin resistance index and worsened lipid profile. Obesity significantly worsened all metabolic and reproductive outcomes measured except for hirsutism when compared to normal weight women with PCOS. Overweight women had no differences in total testosterone, hirsutism, total-cholesterol and low-density lipoprotein-cholesterol compared to normal weight women and no differences in SHBG and total testosterone compared to obese women. Central obesity was associated with higher fasting insulin levels. These results suggest that prevention and treatment of obesity is important for the management of PCOS.</p> <p><strong><sup>&nbsp;</sup></strong></p> J.Shruthi Reddy, V.Hymavathi, M.Shiva Kumar, MD.Sohail, Shivani Sinha, Anjana Saraswathi Copyright (c) 2022 https://pharmacreations.com/jpc/article/view/247 Tue, 26 Jul 2022 00:00:00 +0000