Journal of Pharmacreations
https://pharmacreations.com/jpc
DrSriram Publicationsen-USJournal of Pharmacreations 2348-6295Formulation and in vitro evaluation of controlled release matrix tablets of metoprolol
https://pharmacreations.com/jpc/article/view/318
<p>The present study involves in the formulation and evaluation of Controlled release tablets of Metoprolol (25mg). The objective of the present study was to formulate Metoprolol Controlled release tablets by direct compression method by using Eudragit S 100, HPMC K4 M and HPMC K15 M. MCC was used as diluting agent, Magnesium stearate was used as a lubricant and Talc was used as a glident. This Controlled release the drug up to 12 hours in predetermined rate. The formulated powder blend was evaluated for bulk density, tapped density, compressibility index and angle of repose. The formulated tablets were evaluated for physical characteristics of Controlled release tablets such as thickness, hardness, friability, weight variation and drug content. The results of the formulations found to be within the limits specified in official books. The tablets were evaluated for <em>In-vitro</em> drug release studies by using USP type II dissolution test apparatus. The dissolution test was performed in 0.1 N HCL for 2 hr and phosphate buffer pH 6.8 for 12hrs. The <em>in-vitro</em> cumulative drug release profile of all formulations F1-F12 hours showed good drug release. Hence, Formulation F7 was the most promising formulation as it gives satisfactory release (98.29 %) for 12 hours and F7 found to be the best formulation.</p>Jarupula SunithaB. Manjula K. Balaji
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2024-10-082024-10-08114258268Formulation and evaluation of oral controlled release tablets Of nifedipine
https://pharmacreations.com/jpc/article/view/319
<p>The aim of the present study was to develop controlled release formulation of Nifedipine to maintain constant therapeutic levels of the drug for over 12 hrs. Karaya gum, Acacia and Tragacanth were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. From the dissolution studies it was evident that the formulation (F4) showed better and desired drug release pattern i.e., 98.14 % in 12 hours. It contains the Acacia polymer. It followed Zero order release kinetics mechanism.</p>Bodineni Sudheer Kumar BabuM. Rama KrishnaK. Balaji
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2024-10-082024-10-08114269278Trends In Granulation Techniques
https://pharmacreations.com/jpc/article/view/320
<p>Granulation is a crucial process in pharmaceutical production, specifically in the manufacturing of tablets and capsules. It involves enlarging particles through agglomeration to create free- flowing, dust-free granules that are easy to compress. However, granulation presents various challenges due to the high quality standards required for the granules in terms of uniformity, size, density, hardness, moisture content, compressibility, and stability. There are two main types of granulation processes: wet granulation, which involves the use of liquid, and dry granulation, which does not require liquid. Choosing the appropriate process depends on understanding the physicochemical properties of the drug, excipients, desired flow and release characteristics, among others. Various technologies such as spray drying, roller compaction, high shear mixing, and fluid bed granulation are commonly used in granulation. The field of pharmaceutical granulation technology is continuously evolving, with new and innovative technologies emerging. This review highlights recent advancements in granulation techniques and technologies, including pneumatic dry granulation, reverse wet granulation, steam granulation, moisture-activated dry granulation, thermal adhesion granulation, freeze granulation, and foamed binder or foam granulation, providing a brief description of each development along with its significance and limitations.</p>K. Vinod kumarB. Rama DeviB. Siva saiB. Sai anil kumar DoraG. YeshwanthSK. Ashik
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2024-10-112024-10-11114279285