Journal of Pharmacreations https://pharmacreations.com/jpc Dr.N.Sriram en-US Journal of Pharmacreations 2348-6295 Synthesis of silver nanoparticles using herbal plants and its application to nano-gel systems for treatment of wounds https://pharmacreations.com/jpc/article/view/182 T. Sathish kumar R. Sivakumar Ubaidulla. U Priyanka Sinha Copyright (c) 2021 Journal of Pharmacreations 2021-08-02 2021-08-02 8 3 82 85 Design and optimization of oral osmotic pump based controlled drug delivery system for betahistine dihydrochloride https://pharmacreations.com/jpc/article/view/189 <h4>The aim of the present study was to develop and optimize elementary osmotic drug delivery system of betahistinedihydrochloride to give control release of drug by utilizing the osmosis principle with better patient compliance. Suitable analytical method based on uv-visible spectrophotometer developed for betahistinedihydrochloride. By performing preformulation studies by ft-ir, drug-excipient compatability studies, no interaction was confirmed. Prior to compression, drug and granules were evaluated for flow properties such as angle of repose, loose bulk density, tapped bulk density, % compressibility, and hausner’s ratio. The present study shows that the release of bht could be extended over a period of 12 hours through the design of an osmotic drug delivery system by using peo (mw:1,00,000 gm) as swellable polymer , mannitol as osmogen and ethyl cellulose as semi permeable coating membrane. Hence twice a day administration of this ndds can ensure therapeutic concentration throughout the day and can enhance patient compliance.</h4> <p>&nbsp;</p> G. Yesu Rani M. Uma Devi P. SaiRatnaTeja Sk. Mobhina Y. Jyothsna SP. Raj kumar M. Durgarao Copyright (c) 2021 Journal of Pharmacreations 2021-09-17 2021-09-17 8 3 105 111 Formulation of dispersible tablets of antimalarial drug combination - artemether and lumefantrine https://pharmacreations.com/jpc/article/view/186 <p>For the past two decades, there is an enhanced demand for more patient compliance dosage forms. As a result, the demands for the technologies are increasing three folds annually. Oral delivery is currently the golden standard in the pharmaceutical industry where it is regarded as the safest, most convenient and economical method of drug delivery having the highest patient compliance.</p> <p>The most popular dosage forms being tablets and capsules, one important drawback of these dosage forms however is the difficulty to swallow. To overcome this weakness, scientists have developed innovative drug delivery systems known as dispersible tablets.</p> <p>The main aim of this work is to prepare and evaluate dispersible tablets of Artemether and Lumefantrine using co-processed super disintegrants containing crospovidone and sodium starch glycolate. Ten batches of dispersible tablets Artemether and Lumefantrine along with control formulation tablets were prepared by direct compression method using conventional tabletting equipment and subjected to various evaluation tests. All the formulations were evaluated for pre-compression and post-compression parameters. Results revealed that all the formulated tablets have acceptable physical properties. Thus, it can be summarized that stable Artemether and Lumefantrine dispersible tablets were prepared successfully by using co-processed super disintegrants by direct compression method.</p> Preethi Fernandiz Suresh N Kerryn Joseph A D'Silva Copyright (c) 2021 Journal of Pharmacreations 2021-08-04 2021-08-04 8 3 86 93 Evaluation of dispersible tablets of antimalarial drug combination - artemether and lumefantrine https://pharmacreations.com/jpc/article/view/188 Kerryn Joseph A D'Silva Suresh N Preethi Fernandiz Copyright (c) 2021 Journal of Pharmacreations 2021-08-04 2021-08-04 8 3 94 104