Journal of Pharmacreations

Integrated Study on Neem (Azadirachta Indica) Seed Constituents, Extraction and Anti-Microbial Screening

S. Kannan — 2025-09-02

Screening of medicinal plants for bioactive compounds leads to less expensive new antimicrobial agents with improved safety & efficacy. Azadirachta indica (Neem) is a multipurpose tree with multipurpose tree multiple health benefits. Different parts of the plants are shown to exhibit antimicrobial effects against a wide variety of microorganism. In present study we compared the anti-microbial efficacy of aqueous extracts of seeds of a Azadirachta indica human pathogenic bacteria (Staphylococcus aureus, Escherichia coli pneumonia and skin disease are some types of severe infections occur worldwide. Due to pathogenic bacteria such as Escherichia coli(E.coli) Staphylococcus aureus (S. aureus). These bacteria’s do contribute towards other infection in human and thus lead to towards unhealthy life. Agar well diffusion method and micro-broth dilution methods were used to determine the minimum inhibitory concentration(MIC). Results showed that seed extracts exhibited strong anti-microbial activity against bacteria at all the concentration tested (100,200 & 300 g/ml). Our results suggest that aqueous extracts of Azadirachta indica seed exhibit high anti-microbial activity.

A Review of Moringa Oleifera for Wound Healing

Vigneshwaran. L V — 2025-09-19

The natural process of wound healing restores injured tissues that have lost their integrity. in malaysia, moringa oleifera, sometimes referred as merunggai, has long been used to treat a variety of illnesses, including wounds. The leaves of moringa oleifera are a great source of fibers, minerals, anti-inflammatory, antidiabetic, and antimicrobial properties are all possible with this extract. CENTRAL, pubmed, Google scholar, Science Direct, LILACS, and ClinicalTrails.gov are among the databases that were the subject of 18 in vitro investigations in all; the othr 5 studies examined various plant components in models of excision, incision, desd sopace, abrasion, and burn-included wounds. Significant wound healing powers were demonstrated in all investigations. The majority of research employed various topical formulations of aqueous leaf extract. The analysis of research data was assessed using the ANOVA statistical test. The aims, research design, and results of the listed studies were used to examine the data. there were 1,375 records found in databases,1344 records thet were screened, 25 reports that were searched for retrivel ,17 reports that wee evaluated for elibiblity, and 9 fulltext articles in yhe systematic review. critical findings that had been carefully chosen to satisfy the research inclusion criteria were the basis for nine papers' eligibility. This paper a thorough overview of the plant's pharmacological and phytochemical properties as well as its traditional and medicinal applications. M.oleifera is used pharmacologically and traditionally foe a wide range of pathophysiology disorders. we will go over the many characteristics of the drumstick tree, M.oleifera, with an emphasis on its seversl therspuetics uses . To give patients with acute and chronic wounds receiving at-home or hospital treatment more information, research involving a comprehensive review of the efficacy of moringa oleifers leaves for wound healing is crucial. M. oleifera shown the ability to cure wounds, however more research is necessary to identify the primary bioactive phytochemical and safety.

A Review on Cosmeceutical Perspective of Luffa Acutangula

R. Vidhya Shree — 2025-09-22

Luffa acutangula is known as ridge gourd, it is atropical plant traditionally used in various medicinal systems for its anti-inflammatory, antioxidant, and antimicrobial properties. Recent research highlighted its potential applications in cosmetics due to its rich phytochemical profile, which included flavonoids, saponins, and polyphenols. Furthermore, its mild exfoliating properties, resulting from its natural fibres and enzymes, made it a suitable ingredient in facial scrubs and masks. The luffa acutangula possess several pharmacological activities such as anti-inflammatory, anti-oxidant, anti- microbial and many more the biological active component purporting to have skincare benefits and can be used in the product such as moisturising, antiaging, anti-acne cream, exploitation, etc. the intention of the article of luffa acutangula is to focus on cosmetic importance and its benefits.

Alternative of Herbal Preservatives

Venkatesh. S — 2025-09-22

The cosmetic industry is witnessing a paradigm shift toward the integration of natural ingredients, particularly in the selection of preservatives. Conventional synthetic preservatives, though effective, have raised concerns regarding potential health risks and environmental impact. This review highlights various natural alternatives to synthetic preservatives in cosmetic formulations, with a focus on essential oils, plant extracts (Neem, Curcumin, Aloe vera), and raw materials like honey. These natural agents exhibit significant antimicrobial, anti-inflammatory, and antioxidant properties, making them promising candidates for preserving cosmetic products. Essential oils such as Thymus onites and Cinnamomum zeylanicum demonstrate strong antimicrobial action, often surpassing synthetic preservatives in efficacy. Similarly, plant-based substances like Neem and Curcumin offer broad-spectrum antimicrobial effects and additional therapeutic benefits. Honey, known for its historical use in skin care, contributes both humectant and antimicrobial properties. This review underscores the importance of these natural preservatives in promoting safer, eco-friendly cosmetic formulations.