Journal of Pharmacreations

Evaluation Of Anti Hyperlipidemic Activity Of Sphaeranthus Indicus Leaf Extract On Dexamethasone-Induced Hyper Lipidemia In Rats.

P. Laxmi Prasanna — 2025-05-09

Siddha is one of the oldest medical systems in India, regarded as the foundational medicine of the ancient Tamils and Dravidians in South India. This system not only holds the distinction of being the most ancient but also boasts numerous specialties that surpass those found in Ayurvedic medicine. Sphaeranthus indicus Linn, belonging to the Asteraceae family, is commonly referred to by various names including Munditika, Mundi, Shravana, Bhikshu, Tapodhana, Mahashravani, Shravanahva, and Shravanashirshaka. This plant thrives in moist environments, particularly in plains, and is often found as a weed in rice paddies. In traditional Indian medicine, various parts of the plant such as the leaves, stems, bark, roots, flowers, and seeds are utilized for the treatment of numerous ailments. The plant is characterized by its bitter taste and is known for its stomachic, restorative, alterative, pectoral, demulcent, and soothing properties when applied externally. Research has identified a range of secondary metabolites present in the entire plant and its parts, including eudesmanolides, sesquiterpenoids, sesquiterpene lactones etc. In summary, our findings indicate that Sphaeranthus indicus effectively reduces oxidative stress through free radical scavenging offers protection against lipid peroxidation, and helps regulate hyperlipidemia by lowering serum cholesterol and triglyceride levels, comparable to standard medications. Additionally, phytochemical analyses have indicated the presence of Alkaloids, flavonoids, and Saponins.

Evaluation Of Anti-Ulcer Activity Of Clerodendrum serratum Leaf Extract In Experimental Animal Models

Amatullah Firdous Khanam — 2025-05-03

One of India's oldest medical systems, siddha is thought to have been the primary treatment used by the ancient Tamils and Dravidians in South India. In addition to being the oldest, this system has many specialties that are superior to those utilized in Ayurvedic treatment. A significant medicinal plant, Clerodendrum serratum (L.) Moon. (Verbenaceae) grows in tropical and warm temperate locations such as Africa, Southern Asia, Malaysia, and the forests of India and Sri Lanka. For a long time, it has been used in India to cure fever, malarial fever, respiratory conditions, rheumatism, inflammation, and discomfort. Based on the current findings and reports, it can be said that Clerodendrum serratum's anti-ulcer activity may be partially caused by acid inhibition and primarily by the modulation of defensive factors through an improvement in gastric cytoprotection. The research findings indicated that C. serratum shows potential as a natural treatment for asthma, suggesting the need for additional investigation into its bioactive elements and underlying molecular processes. Furthermore, phytochemical studies have revealed the existence of alkaloids, flavonoids, and saponins.

Development And Assessment Of Oral Disintegrating Films Made Of Dexlansoprazole Utilizing Natural Polymers

Jajala Balamani — 2025-05-08

The medication's efficacy and safety profile may be enhanced, dosage may be decreased, and the onset of action may be accelerated with oral disintegrating films. Compared to other conventional dose forms, it dissolves more quickly, remains more stable, and has a longer half-life. Dexlansoprazole (DXP) was used for the sublingual route in order to produce fast-dissolving films that dissolves in saliva quickly and without the need for water. DXP ODFs were designed to improve bioavailability and patient compliance. In order to assist the aged, bedridden, and mentally ill, the recipes were developed. The influence on the dissolution profile is measured using DXP. The solvent casting method was used to create the oral disintegrating films (ODFs), which contained PEG 400 as an active ingredient and plasticiser along with natural polymers including guar gum and chitosan in different proportions. The results showed that the medicine vanished quickly. According to this study, DXP might be administered orally using an oral disintegrating film. ODF formulations release all of the drug in 20 minutes after dissolving smoothly and readily. There was no particle matter or residue left after disintegration. It was found that the solvent casting technique worked well for creating the rapidly dissolving DXP films. Oral disintegrating films (ODF) have been used successfully with patients who are immobile, schizophrenic, or travelling when there is no access to water. Prepared films showed a faster start of action and a higher rate of dissolution, which resulted in better patient compliance, effective treatment, and future use growth.

Formulation, Optimization And Evaluation Of Mebendazole Orodispersible Tablets Utilising Natural Polymers

Gajjala Supraja — 2025-05-08

Oral dispersible tablets (ODTs) are patient friendly dosage form that rapidly disintegrant or dispersed in mouth without the need of water. In the present investigation eight ODT formulations of mebendazole, an antiretroviral drug, were prepared using different superdisintegrants Oral dispersible tablets (ODTs) are patient friendly dosage form that rapidly disintegrant or dispersed in mouth without the need of water. In the present investigation eight ODT formulations of mebendazole, an antiretroviral drug, were prepared using different superdisintegrants Oral dispersible tablets (ODTs) are a patient-friendly dose form that swiftly disintegrants or disperses in the mouth without the necessity of water. This study involved the preparation of nine orodispersible tablet formulations of mebendazole (MBZ), an antihelminthic medication, utilizing several natural superdisintegrants. The solubility and dissolving rate of the therapeutic molecules used in this study were improved by using starch tartrate, sodium starch glycolate and croscarmellose sodium as super disintegrating agents. The formulations were all made utilizing 16-station rotary tablet punching machine and the direct compression method, with a 7.5 mm punch. The next step was to compress the improved mixture into tablets and test their solubility in a controlled laboratory setting. The combination of formulations exhibited favorable flow characteristics, including depth of repose, tapped density, and bulk density. The produced tablets passed all quality control assessment criteria according to I.P. limits and demonstrated good post-compression parameters. Formulation MT3 was determined to be the most effective since it released the most medicine (101.28 percent) in the shortest duration of time (15 minutes) and disintegrated within 30.51 seconds. With a dosage of 37.5 mg, the MT3 formulation includes starch tartrate (ST) as a super disintegrant.

Development And Assessment Of Oral Disintegrating Films Containing Hydrochlorothiazide

Myadam Sunitha — 2025-05-09

The medication's efficacy and safety profile may be enhanced, dosage may be decreased, and the onset of action may be accelerated with oral disintegrating films. Compared to other conventional dose forms, it dissolves more quickly, becomes more stable, and has a longer half-life. Hydrochlorothiazide (HCT) is a antihypertensive medication used for the sublingual route in order to produce fast-dissolving films that dissolves in saliva quickly and without the need for water. HCT oral disintegrating films were designed to improve bioavailability and patient compliance. The impact on the dissolution profile is measured by HCT. The solvent casting method was used to create the HCT oral disintegrating films (ODF) using natural polymer mango peel pectin and water soluble polymer HPMC E15 of various concentration and mannitol as a plasticizer. The results showed that the medicine vanished quickly. ODF formulations are smooth and easy to swallow, and disintegration time of HF8 formulation containing mango peel pectin 4% was 12 sec while HPMC E15 (HF4) disintegrates in 22 sec. As compare to synthetic polymer, natural polymer mango peel pectin showed lesser disintegration time. HF8 releases the entire medicine within 20 minutes. Upon disintegration, no trace or fragment debris was found. Therefore, based on dissolution tests and disintegration time, the HF8 formulation was determined to be the most optimal formulation among all.

Formulation And Invitro Evaluation Of Quetiapine Fumarate Oral Dispersible Tablets Using Co-Processed Super Disintegrant Technique

Tanveer Fathima — 2025-05-09

Orally disintegrating tablets (ODTs) quickly break down or dissolve in the mouth without the need for water. The demand for orally disintegrating tablets (ODTs) has experienced a significant surge, leading to a substantial expansion of this field within the pharmaceutical business and academics. Orally dissolving tablets are becoming increasingly popular compared to regular tablets since they are convenient to administer and suitable for patients. This study aims to create orally disintegrating tablets of Quetiapine fumarate (QTP). The tablets were formulated using a novel technique called co-processed super disintegrates technology. The preparations were made using the direct compression approach. The optimal flow properties, such as angle of repose, bulk density, and tapped density, were demonstrated by the amalgamation of all the formulations. The produced tablets exhibited favorable post-compression characteristics and successfully met all quality control evaluation criteria according to the I.P limits. The QF4 formulation exhibited the highest drug release, specifically 99.21%, within a 30-minute timeframe. Therefore, it is regarded as the optimum formulation. The QF4 formulation includes second control point (CP2) as a highly effective disintegrant at a strength of 10 mg. The second control point (CP 2) consists of a mixture of CCS and CP in a ratio of 1:2. The current investigation showcased the capacity for swift assimilation, enhanced availability for the body to utilize, successful treatment outcomes, and adherence from patients. The rapid beginning of action and improved anti-psychiatric activity of QTP were observed in fast dissolving tablets made by utilizing combined super disintegrates technology of QTP.

Evaluation Of Anti-Epileptic Properties From Flowers Of Mussaenda Philippica In Isoniazid-Induced Convulsions In Wistar Rats

Afreen Begum — 2025-05-15

Epilepsy is a chronic neurological disorder characterized by recurrent seizures, often associated with excessive neuronal activity. Current antiepileptic drugs have limitations due to side effects and lack of efficacy in some patients, prompting the need for alternative therapies. This study investigates the antiepileptic potential of ethanolic extract of Mussaenda philippica (EEMP) flowers using maximal electroshock (MES) and isoniazid (INH)-induced convulsion models in Wistar rats. Preliminary phytochemical analysis revealed the presence of alkaloids, flavonoids, phenols, glycosides, saponins, and terpenoids. In the MES model, EEMP significantly reduced seizure parameters including flexion, extension, clonus, stupor, and recovery time. It also improved percentage protection and increased gamma-aminobutyric acid (GABA) levels, indicating enhancement of inhibitory neurotransmission. In the INH-induced model, EEMP delayed seizure onset, reduced mortality, and demonstrated 100% protection in higher doses. Histopathological examination confirmed increased neuronal density and reduced brain damage. These effects are likely due to the flavonoid content and antioxidant properties of M. philippica, which may act by inhibiting GABA transaminase or promoting GABA synthesis. The results suggest that Mussaenda philippica possesses promising antiepileptic activity and may serve as a potential natural alternative for managing epilepsy.