Journal of Pharmacreations

A Review of Analytical Methods for Losartan Potassium Estimation in Pharmaceutical Preparation

A. Raja Reddy — 2023-04-04

Angiotensin II receptor blockers, the first novel type of antihypertensive medication, includes losartan potassium. High blood pressure, commonly known as hypertension, is a disorder that develops when the blood pressure is too high. The smaller blood arteries (the arterioles) constrict, which causes increased blood pressure against the artery walls and makes the heart work harder to maintain blood pressure. This condition is known as hypertension. The tablet-based medication has been marketed as "the antihypertensive for the '90s and beyond" with a reduced incidence of adverse effects than (is) typically associated with other antihypertensives. The analytical methods Based on previously published articles from a variety of journals, this study includes UV spectroscopy, Reverse phase-high performance liquid chromatography (RP-HPLC), High performance thin layer chromatography (HPTLC), Liquid chromatography/mass spectrometry (LC/MS), and Ultra performance liquid chromatography mass spectrometry(UPLCMS).

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Govind Shukla — 2023-04-04

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Nanotechnology approaches to systemic lypus erythematus

Naga Chandrika Pallam — 2023-04-22

Systemic lupus erythematous is a autoimmune disease which is a chronic multisystemic heterogenous disease caused by self-destruction of system by production of autoantibodies due to self-antigens. Novel therapeutic approaches are necessary to treat SLE despite tremendous advancements in therapeutic alternatives and greater understanding of the pathophysiology. An innovative approach that may significantly improve the treatment of serious diseases is immune system modulation based on nanotechnology. Therapeutic delivery may be enhanced by nanoparticle-based delivery systems that target inflammatory tissue or a particular cell for drug administration. Non-steroidal anti-inflammatory drugs, antimalarials, corticosteroids, and cytotoxic/immunosuppressive drugs have all been used to treat SLE in the past, but perhaps more recently, the focus has focused on developing biological agents that can inhibit autoreactive B cells, prevent cytokine signalling, and promote the growth of regulatory T cells. In this review article is being discussed about new technical approaches to treat the systemic lupus erythematous. In 2020, the U.S. market for drugs for Systemic lupus erythematosus (SLE) is anticipated to be worth $50.8 million. With a predicted market size of US$46.9 million by 2027 and a CAGR of 5.7% from 2020 to 2027, China, the second-largest economy in the world, is expected to be the fastest-growing region.

Cubosomes in cancer therapy

P. Neeraja — 2023-05-14

Cubosomes are bicontinuous cubic phase liquid crystals have many properties that make them appealing as a universal vehicle for drug delivery and it was considered as the drug Nano carrier due to their great potential as an alternative drug delivery system relative to liposome. cubosome have great potential in drug Nano formulations for melanoma therapy owing to their potential advantages, including high drug payloads due to high internal surface area and cubic crystalline structures, relatively simple preparation method, biodegradability of lipids, the ability of encapsulating hydrophobic, hydrophilic and amphiphilic substances, targeting and controlled release of bioactive agents. Cubosome dispersions are bio adhesive and biocompatible. The application of cubosomes for intravenous drug delivery is an ambitious one; however, these Nano carriers may find accelerated applications for oral, ocular and topical delivery of poorly water soluble drugs, there by offering an alternative, yet, a cost effective opportunity in formulation science. Cubosomes are attractive nano vehicles for loading and delivery of proteins and peptides but the reported studies are still on a fundamental level and different aspects in terms of structural and morphological characteristics of these soft Nano carriers, loading capacity of bio macromolecules and their release should be addressed. Future development of cubosome based intravenous Nano medicines should address blood compatibility at early stages of formulation development.