Journal of Pharmacreations

Evaluation of dispersible tablets of antimalarial drug combination - artemether and lumefantrine

Kerryn Joseph A D'Silva — 2021-08-04

Live long life, stay healthy with pugos antioxidant- antiageing nutrition

GovindShukla — 2021-10-19

Antioxidants are our first line of defense against free radical damage, and are critical for maintaining optimum health and wellbeing.The need for antioxidants becomes even more critical with increased exposure to free radicals. Pollution, cigarette smoke, drugs, illness, stress, and even exercise can increase free radical exposure. Because so many factors can contribute to oxidative stress, individual assessment of susceptibility becomes important. Antioxidants terminate the chain reactions by removing free radical intermediates, and inhibit other oxidation reactions. They do this by being oxidized themselves, so antioxidants are often called as reducing agents. Antioxidants are widely used as ingredients in dietary supplements and have been investigated for the prevention of diseases such as cancer, coronary heart disease and even altitude sickness. The present paper reviews the role of Pugos Antioxidant Nutrition for Protection against Pollution, tobacco, cigarette smoke, drug addiction, illness, stress, alcohol, medications, trauma, cold, infections, poor diet, toxins, radiation.

Synthesis of silver nanoparticles using herbal plants and its application to nano-gel systems for treatment of wounds

T. Sathish kumar — 2021-08-02

Design and optimization of oral osmotic pump based controlled drug delivery system for betahistine dihydrochloride

G. Yesu Rani — 2021-09-17

The aim of the present study was to develop and optimize elementary osmotic drug delivery system of betahistinedihydrochloride to give control release of drug by utilizing the osmosis principle with better patient compliance. Suitable analytical method based on uv-visible spectrophotometer developed for betahistinedihydrochloride. By performing preformulation studies by ft-ir, drug-excipient compatability studies, no interaction was confirmed. Prior to compression, drug and granules were evaluated for flow properties such as angle of repose, loose bulk density, tapped bulk density, % compressibility, and hausner’s ratio. The present study shows that the release of bht could be extended over a period of 12 hours through the design of an osmotic drug delivery system by using peo (mw:1,00,000 gm) as swellable polymer , mannitol as osmogen and ethyl cellulose as semi permeable coating membrane. Hence twice a day administration of this ndds can ensure therapeutic concentration throughout the day and can enhance patient compliance.

Formulation of dispersible tablets of antimalarial drug combination - artemether and lumefantrine

Preethi Fernandiz — 2021-08-04

For the past two decades, there is an enhanced demand for more patient compliance dosage forms. As a result, the demands for the technologies are increasing three folds annually. Oral delivery is currently the golden standard in the pharmaceutical industry where it is regarded as the safest, most convenient and economical method of drug delivery having the highest patient compliance.

The most popular dosage forms being tablets and capsules, one important drawback of these dosage forms however is the difficulty to swallow. To overcome this weakness, scientists have developed innovative drug delivery systems known as dispersible tablets.

The main aim of this work is to prepare and evaluate dispersible tablets of Artemether and Lumefantrine using co-processed super disintegrants containing crospovidone and sodium starch glycolate. Ten batches of dispersible tablets Artemether and Lumefantrine along with control formulation tablets were prepared by direct compression method using conventional tabletting equipment and subjected to various evaluation tests. All the formulations were evaluated for pre-compression and post-compression parameters. Results revealed that all the formulated tablets have acceptable physical properties. Thus, it can be summarized that stable Artemether and Lumefantrine dispersible tablets were prepared successfully by using co-processed super disintegrants by direct compression method.

Lactonova nutrition for menopause mothers

Govind Shukla — 2021-09-30

Menopause is a natural phase in a woman’s life that can be thought of as a time ofovarian retirement. At birth women have about one million eggs in their ovaries. At puberty ovulation starts and eggs are released by the ovaries each month for the purpose of conception. As the years go by, the amount of eggs gradually declines until menopause, when the ovaries shut down and stop producing estrogen and progesterone,the two main female sex hormones. Menopause occurs when ovulation ceases and a woman can no longer conceive naturally. After menopause the adrenal glands, which supply some sex hormones throughout life, become the primary source. Women who have poor adrenal function, which can be caused by chronic stress, poor diet, lack of sleep, or excessive caffeine, are not able to provide adequate hormone amounts, and may have more severe menopausal symptoms. Estrogen can also be produced in the fat cells from androgens.There are many lifestyle measures and Lactonova Nutrition supplements that can promote hormone balance and ease menopausal concerns.