Journal of Pharmacreations Dr.N.Sriram en-US Journal of Pharmacreations 2348-6295 Prevalance of anemia in patients with various clinical condition in a private hospital <p>The objective of the study is to evaluate the prevalence of anemia in a large population of patients in a Multispeciality Hospital. A Retrospective study was carried out at Vivekanandha Medical Care Hospital, Tiruchengode. The study was conducted for 6 months. It was done in anemic patients with various clinical conditions. The patients details and prescriptions were analyzed and it was attached to the data analysis form Microsoft excel 2019 was used to analyze the data. In this Folic acid was utilized by the patients having anemia with stroke. Drugs like pantoprazole, amlodipine was utilized by the patients having anemia with Hypertension. Drugs like ranitidine, amlodipine was utilized by patients having anemia with Diabetes Mellitus. The major co-morbidity of anemia was Hypertension and Diabetes Mellitus. The age of the population was between 15-95 years. The prevalence was higher in male than female with Hypertension and Diabetes Mellitus. This study provides additional knowledge to the Healthcare providers to improve the health, recommended that the primary healthcare to be strengthened and high priority should be given to aspects such as prevention, early diagnosis and treatment of anemia.</p> S.Anandkumar R.Aishwarya K.Ananthi S.Brindha A.A.Gayathri M.Gomathi E. Jennifar Copyright (c) 2022 2022-04-05 2022-04-05 9 2 37 42 Extraction, Phytochemical Analysis and Functional Group Confirmation of Carica Papaya Leaf by FTIR Spectroscopic Method <p>The aim of this study is to extract <em>Carica papaya</em> plant leaf, analyse phytochemical analysis, and confirm functional groups using FTIR analysis.To extract Carica papaya and perform preliminary phytochemical analysis to identify phytochemical ingredients contained in the leaf extract and confirm the functional group of the active constituents present in the extract using the FTIR technique.The preliminary phytochemicals of Ethanol, Methanol, and Hydro-Alcohol extracts of Carica papaya were evaluated to determine the presence of alkaloids, flavonoids, phenols, saponins, terpenoids, steroids, and tannins to confirm the functional group of the active constituents present in the extract by using the FTIR method analysis. Saponins, steroids, carbohydrates, alkaloids, glycosides, proteins and amino acids, flavonoids, and other related phytochemicals having N-H bonds were found in Carica papaya leaf extract, which was validated by qualitative phytochemical analysis.From the results of the study was concluded that ethanolic extract of <em>Caricva papaya</em> has the Alkyl halides, carboxylic acids, amines, amides, Alkenes, Ethers, Alcohol compounds.These amines and carboxylic acids are used for Dengue, Dyspepsia,hyperacidity,dysentery and constipation.</p> M. Sarbudeen R. Manivannan M. Balaji S. Vijayanand L. Pradeep S. Dhivakar S. Nandhini Copyright (c) 2022 2022-04-12 2022-04-12 9 2 43 48 Formulation and evaluation of sustained release matrix tablets of a selective antihypertensive drug <p>The present work was to formulate and evaluate sustain release matrix tablets of Valsartan, an angiotensin II Receptor type 1 antagonist. Sustain release formulation are those which delivers the drug locally or systemically at a predetermined rate for a fixed period of time. The matrix tablet was prepared by direct compression method using by various concentration of chitosan and sodium alginate with combination of various release retardant polymer. The powder mixtures were subjected to various pre-compression parameters such as angle of repose, bulk density, tapped density and Carr’s index shows satisfactory result and the compressed tablets are evaluated for post-compression parameters such as weight variation, thickness, hardness, friability, drug content, <em>in-vitro </em>dissolution and stability studies. <em>In-vitro </em>dissolution studies were carried out for 24 hours using 0.1 N HCL for first 2 hours and pH 6.8 phosphate buffer for 24 hours and the result showed that formulations F<sub>4</sub> and F<sub>7</sub> showed good dissolution profile to control the drug release respectively. Formulation containing higher concentration of chitosan and sodium alginate along with polymers sustained the drug release for the period of 24 hours. The compatibility of the drug, polymers and other excipients were determined by FT-IR Spectroscopy. Results showed that the drug was compatible with polymers and other excipients. The release data was fitted to various mathematical models such as Zero-order, First-order, Higuchi equation and Korsmeyer- Peppas model to evaluate the kinetics and the drug release. The drug release followed first order and the mechanism was found to be non-Fickian. The stability studies were carried out for 3 months and result indicates that the selected formulations (F<sub>4</sub> and F<sub>7</sub>) were stable.</p> S. Chandra N. Senthil Kumar S. Shihabudeen P. Dhivya Bharathi S. Sangeetha S. Kavi Bharathi Copyright (c) 2022 2022-05-09 2022-05-09 9 2 49 58 Natural Kalon Lueur soap Vs Synthetic Beauty soap which is the best one <p>Natural Kalon Lueur soap Vs Synthetic Beauty soap which is the best one. Beauty soap contain hundreds of chemicals and compounds that are toxic to our body. Some of these include skin irritants and even&nbsp;endocrine disruptors which&nbsp; interfere with the body’s hormonal system and potentially have developmental, reproductive, neurological, and immune adverse effects, According to the National Institute of Environmental Health Sciences these chemicals are known to cause irritation to the skin and interfere with the normal functioning of reproductive and thyroid hormones, where as &nbsp;Kalon Lueur &nbsp;Soap, The &nbsp;Natural&nbsp; Hydrating, Moisturizing, Nourisning &amp; Cleansing soap is &nbsp;enriched with Aquaxyl &amp; Vitamin E TGPS<strong>. </strong>This Unique blend is simply nourishing and highly oxidizing in nature, Helps fight the free radicals (caused due to pollution and sun exposure), there by leaving the skin smooth and hydrated skin. 3d hydration Hydra concept in Kalon Lueur Soap offers circulation of water optimized throughout all layers of the skin, up to the surface. It moisturizes and restructures the skin barrier reinforced in 24 hours which limits the water loss thus Promotes softer, smoother skin in 28 days. This makes the skin more resistant and better equipped to combat external aggression.</p> <p><strong>&nbsp;</strong></p> Govind Shukla C. Subrahmanyam Mantipally Yamuna C.J Sampath Kumar Copyright (c) 2022 2022-05-09 2022-05-09 9 2 59 62 Analytical method development and validation for clomipramine and fluvoxamine by using rp-hplc technique G. Sri Lakshmi K.Kavitha Khaja Azher Uddin S.Kiranmayi N.Krishna Priya S.Madhuri Copyright (c) 2022 2022-05-09 2022-05-09 9 2 63 69 Design and invitro evaluation of selegiline patches for transdermal drug delivery system <p>Selegiline, also known as L-deprenyl is a medication which is used in the treatment of Parkinson's disease and major depressive disorder. It is provided in the form of a capsule or tablet taken by mouth for Parkinson's disease and as a patch applied to skin for depression. In present study transdermal drug delivery of Selegiline was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route.</p> <p>&nbsp;</p> L.Rajini Arjun goje J.Shashank A.Sirisha B.Shirisha J.Shivani S.Sowjanya Copyright (c) 2022 2022-05-09 2022-05-09 9 2 70 77 Design and in-vitro charecterization of finasteride buccal tablets E.Beaula rani Arjun goje M.Manjula A.Manvita Mirza.A.Baig R.Mounika E.Mounika Copyright (c) 2022 2022-05-09 2022-05-09 9 2 78 84 Design, Development and Characterization of Oral thin films of Amlodipine besylate,using different polymers, plasticizers and super disintegrants. <p>The&nbsp;aim&nbsp;of&nbsp;this&nbsp;study&nbsp;was&nbsp;to&nbsp;prepare&nbsp;pullulanbased&nbsp;orally&nbsp;disintegrating&nbsp;films&nbsp;(ODFs)&nbsp;containing&nbsp;amlodipine&nbsp;besylate,&nbsp;an&nbsp;antihypertensive&nbsp;drug,&nbsp;by&nbsp;the&nbsp;solvent&nbsp;casting&nbsp;method.&nbsp;For&nbsp;this&nbsp;purpose,&nbsp;nine&nbsp;different&nbsp;ODF&nbsp;formulations&nbsp;(F1F9)&nbsp;were&nbsp;prepared&nbsp;by&nbsp;using&nbsp;different&nbsp;plasticizers&nbsp;(glycerol,&nbsp;sorbitol,&nbsp;propylene&nbsp;glycol)&nbsp;and&nbsp;different&nbsp;superdisintegrants&nbsp;(croscarmellose&nbsp;sodium,&nbsp;sodium&nbsp;starch&nbsp;glycolate,&nbsp;crospovidone).&nbsp;FD&amp;C&nbsp;Green&nbsp;and&nbsp;aspartame&nbsp;were&nbsp;used&nbsp;as&nbsp;coloring&nbsp;agent&nbsp;and&nbsp;sweetener,&nbsp;respectively.&nbsp;According&nbsp;to&nbsp;the&nbsp;results&nbsp;of&nbsp;preformulation&nbsp;studies,&nbsp;the&nbsp;optimum&nbsp;ODF&nbsp;(F9)&nbsp;was&nbsp;determined&nbsp;and&nbsp;various&nbsp;characterization&nbsp;studies&nbsp;such&nbsp;as&nbsp;uniformity&nbsp;of&nbsp;mass,&nbsp;film&nbsp;thickness,&nbsp;surface&nbsp;pH&nbsp;of&nbsp;films,&nbsp;and&nbsp;mechanical&nbsp;properties&nbsp;(such&nbsp;as&nbsp;elongation&nbsp;at&nbsp;break,&nbsp;tensile&nbsp;strength,&nbsp;Young's&nbsp;modulus,&nbsp;and&nbsp;folding&nbsp;endurance),&nbsp;moisture&nbsp;content,&nbsp;disintegration&nbsp;time,&nbsp;uniformity&nbsp;of&nbsp;content&nbsp;and&nbsp;dissolution&nbsp;test,&nbsp;X.ray,&nbsp;DSC,&nbsp;SEM&nbsp;and&nbsp;short&nbsp;term&nbsp;stability&nbsp;analysis&nbsp;were&nbsp;performed&nbsp;on&nbsp;this&nbsp;formulation.</p> Sunil mekala Athota Sonia Chava Alekhya D.Venkata Pavan K Bharath Kumar V.Pravallika Copyright (c) 2022 2022-05-11 2022-05-11 9 2 85 93 Analytical method development and validation for clomipramine and fluvoxamine by using RP-HPLC technique K.Kavitha Khaja Azher Uddin S.Kiranmayi N.Krishna Priya S.Madhuri G. Sri lakshmi Copyright (c) 2022 2022-05-30 2022-05-30 9 2 94 100 Analytical method development and validation forofloxacin and methazolamide by using RP-HPLC <p>On the basis of experimental results, the proposed method is suitable for the quantitative determination of Ofloxacin and Methazolamide in pharmaceutical dosage form. The method provides great sensitivity, adequate linearity and repeatability.&nbsp; &nbsp;The estimation of Ofloxacin and Methazolamide was done by RP-HPLC. The Phosphate buffer was pH 4.6 and the mobile phase was optimized which consists of MEOH : Phosphate buffer mixed in the ratio of 70:30 % v/ v. A Symmetry C18 (4.6 x 150mm, 5mm,</p> <p>&nbsp;</p> K.Silpa A.Sai Shilpa B.Sandya M.Saritha N.Seetharamulu Shabista Fathima Copyright (c) 2022 2022-05-30 2022-05-30 9 2 101 107 Analytical method development and validation of droperidol and fentanyl citrate in bulk and pharmaceuticl dosage form by RP-HPLC <h4 style="text-align: justify; margin: 0in -.8pt .0001pt 0in;"><span style="font-size: 10.0pt;">A new method was established <span style="letter-spacing: .1pt;">for </span>simultaneous estimation of Droperidol and fentanyl citrate <span style="letter-spacing: .15pt;">by </span>RP-HPLC method. The chromatographic conditions were successfully developed for the separation of <span style="letter-spacing: .3pt;">Droperidol </span><span style="letter-spacing: .25pt;">and </span><span style="letter-spacing: .3pt;">fentanyl citrate </span><span style="letter-spacing: .2pt;">by </span>using <span style="letter-spacing: .3pt;">Agilent </span><span style="letter-spacing: .1pt;">C18 </span>5µm (4.6*250mm) column, flow rate was 1ml/min, mobile phase ratio was <span style="letter-spacing: .1pt;">Phosphate </span>buffer ph 4.0: ACN (30:70%v/v), detection wave length was 254nm. </span></h4> V. Nagasravani A. Srujana K. Sujatha G. Sumana G. Sunitha V. Suresh Copyright (c) 2022 2022-05-30 2022-05-30 9 2 108 114 RP- HPLC method for simultaneous determination of metformin and canagliflozin in pharmaceutical dosage form B.Sree Devi G.Bhavani K.Bhavani T.Chetan Singh S.Gayatri N.Harish Copyright (c) 2022 2022-05-30 2022-05-30 9 2 115 119 Analytical method development and validation for the simultaneous estimation of hydrochlorthiazide and reserpine by using rp-hplc technique <p>A new method was established for simultaneous estimation of Reserpine and Hydrochlorothiazide by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Reserpine and Hydrochlorothiazide by using Zodiac sil C18 column (4.6×150mm)5µ, flow rate was 1ml/min, mobile phase ratio was (70:30 v/v) methanol: phosphate buffer(KH2PO4and K2HPO4) .</p> A. Sravani G. Ramyasri G. Rohitha G. Sadhana K. Saikanth B. Saimanisha Copyright (c) 2022 2022-05-31 2022-05-31 9 2 120 125 A review article on scoliosis <p>Scoliosis is called idiopathic when no other underlying disease can be identified..The etiology of adolescent idiopathic scoliosis (AIS) is still unknown despite many years of researcheffort of. Theories on AIS’s etiology have included mechanical,harmonal,Metabolic, Neuromuscular,growth and genetic abnormalities.skeletally immature patients with adolescent idiopathic scoliosis are at risk of curve progression.The adolescent onset pf severe idiopathic scoliosis has traditionally been evaluated using standing posteroanterior radiographs of the full spine to assess lateral curvature with the cobb method.scoliosis in children of school age and above primarily occurs in girls.The therapeutic goal in children is to prevent Progression.In children, scoliosis of 20 degree or more should be treated with a brace,and scoliosis of 45 degree or more with surgery.</p> MadhavReddy E. Harikrishna M. Anitha Ch. Pushyaraagam B. Vinod Copyright (c) 2022 2022-06-01 2022-06-01 9 2 126 130 Kalon lueur Face Wash cum Body Wash cleansing gel: Provide Natural nutrients and moisturizing elements to deeper skin layers while cleaning skin. <p>Face cleansers are designed to thoroughly and deeply cleanse our skin’s pores. Unlike regular soap and water (which can actually dry out your skin and strip away protective oils), cleansers are specially formulated products that have ingredients that imbue them with a number of benefits. Well-made cleansers can clean out your pores of dirt, debris and skin oil, remove sebum: a mixture of oil and debris that’s naturally formed throughout the day, clean away dead skin cells which collect over time, provide nutrients and moisturizing elements to your deeper skin layers while cleaning at the same time. The best cleansers kalon leaur face wash cum body wash cleansing gel use natural ingredients and will feel great on our skin.</p> <p><strong>&nbsp;</strong></p> GovindShukla C.Subrahmanyam Akanksha Sonal Khess Sandeep kunche C.J.Sampath Kumar Copyright (c) 2022 2022-06-01 2022-06-01 9 2 131 136 Formulation and evaluation of anti-hypertensive buccal tablets (labetalol HCL) <p>The purpose of this research was to develop and characterize Bioadhesive buccal tablets of Labetalol using sodium alginate, xanthan gum and Ethylcellulose.&nbsp; The tablets were evaluated for weight variation, thickness, hardness, friability, surface pH, mucoadhesive strength, swelling index, in vitro drug release. The swelling index, friability and in vitro drug release. F3 formulation was considered optimum based on good Bioadhesive strength and maximum similarity factor. The drug release from optimum batch followed zero order kinetics with non-Fickian diffusion. Drug and excipients compatibility study showed no interaction between drug and excipients. Stability study of optimized formulation showed that tablets were stable at accelerated environment condition. Thus, buccal adhesive tablet of Labetalol could be an alternative route to bypass hepatic first pass metabolism and to improve bioavailability of Labetalol.</p> Sayyed Wamique Aquil H. Parameshwar A.V. Jithan Mekala Sai Lakshmi Chandrakanth Copyright (c) 2022 2022-06-07 2022-06-07 9 2 137 144 Formulation and evaluation of acyclovir sustained release matrix tablets <p>The aim of the present work is to Formulate and Evaluate controlled release of Acyclovir matrix tablets used for treatment of viral infections.&nbsp; Development of SR Acyclovir is proposed considering the adverse event profile and high fluctuation index of Acyclovir observed with SR dosage forms. In the present work, attempts were made to formulate and evaluate controlled release of matrix tablets of Acyclovir.&nbsp; Acyclovir was subjected to preformulation studies, based on the results obtained Acyclovir controlled release tablets were successfully formulated. Formulations prepared by direct compression technique using sodium alginate and xanthan gum as control release polymers. Set of trials were formulated for which Acyclovir evaluated parameters (bulk density, tapped density, compressibility index, hausner’s ratio, weight, thickness, hardness) were found to lie within the specifications Dissolution study was performed in USP type II apparatus at 100 RPM in 0.1 HCL for 2 hours followed by pH 1.2 and pH 6. 8 phosphate buffer.&nbsp; From the results of the invitro study it appears that the release of the Acyclovir was significantly influenced by the characteristics of the polymer used.</p> <p><strong>&nbsp;</strong></p> Shaik Ubaid Khaleel H. Parameshwar A.V. Jithan M. Sai Lakshmi G.Preeti Raj Copyright (c) 2022 2022-06-07 2022-06-07 9 2 145 149 Evaluation of chronic kidney diseases and realted comorbidities <p>Chronic kidney disease (CKD) is commonly comorbid with hypertension, diabetes, and cardiovascular disease (CVD). However, the extent of comorbidity in CKD across a range of concordant (shared pathophysiology and/or treatment) conditions and discordant (unrelated pathophysiology and/or different or contradictory treatment) conditions is not well documented. Kidney diseases are emerging non-communicable ailments in Saudi Arabia and rest of the world. Among top ten diseases in 2017 in Saudi Arabia, chronic kidney disease was the 4<sup>th</sup>&nbsp;common cause of most of the deaths in the kingdom. Hence, the study aimed at determining the major concomitant chronic disorders and their association with kidney diseases in Hail region.</p> Geetha rani Valaparla K.Prasanthi S.Sandya Y.Swapna G.Teja Copyright (c) 2022 2022-06-07 2022-06-07 9 2 150 152