Main Article Content
Abstract
The Controlled released tablets containing Lamivudine were successfully prepared by direct compression by using Xanthum, Guar gum, HPMC, and CMC. The physiochemical evaluation results for the granules of all trials pass the official limits in angle of repose, compressibility index .The prepared granules were also maintained the physiochemical properties of tablets such as thickness, hardness, weight variation, friability and uniformity of drug content. The optimized formulation contains the average thickness of 2.43±0.25, average hardness of 7.3±0.57, average weight of 399 ± 1.11, friability of 0.08±0.57and drug content 98.22±0.57% .BasedonvariousevaluationparametersformulationsF5was selectedas optimizedformulationandwerefurthersubjectedforcomparativeinvitrodrugrelease studies but among this F5 was optmised based highest percentage of drug release. Resultsrevealedthatalltheformulatedtabletshadacceptablephysicalproperties andshowedreleaseupto97%in24Hrs.The optimized formulationwassubjectedforZeroorder,First order,Higuchimatrix, and thenPeppasmodel. The kinetic studies revealed that the formulation follows zero order indicates that rate of drug release is independent upon concentration.