Main Article Content
Abstract
The purpose of the present investigation is to formulate fast dissolving oral films of Loratidine for the treatment of allergic rhinitis and urticaria. Films were prepared by solvent casting method using Natural Polymers Xanthan gum,GuarGum,SodiumAlginate,Aloe Vera Powder as the film forming polymer and PEG-400 as the plasticizer. Vanillin was used as taste masking agent in the formulations. Sodium Alginate has excellent film forming capacity with rapid hydration power which leads to rapid disintegration of film upon contact with saliva. The concentrations of the polymers and plasticizer were selected as independent variables. The observed independent variables were found to be most satisfactory formulation which demonstrates the feasibility of the optimization procedure in successful development of fast dissolving oral film containing loratidine by using Sodium Alginate, PEG-400 and Vanillin as key excipients.