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Abstract
The oral disintegrating tablets of Amiodarone with sufficient mechanical strength, acceptable taste and smaller disintegration time were achieved employing suitable superdisintegrants and other excipients at optimum concentration. FTIR studies revealed that there was no shift in peaks, indicating there is no interaction between Amiodarone and other ingredients used. Among three super disintegrants used Croscaramellosesodium and SLS combination showed better performance in disintegration time when compared to crospovidone and sodium starch glycolate used alone. In the invitrodissolution study comparison among all formulations, F10 showed best results. So the formulation of F10 was found to be best among all other formulations, because it has exhibited good taste and faster disintegration time when compared to all other formulations.