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Abstract
The Bilayered tablets containing Metformin and telmisartan were successfully prepared by direct compression method respectively. The physiochemical evaluation results for the powdered blend of all trials pass the official limits in angle of repose, compressibility index. The prepared blend for IR release were also maintained the physiochemical properties of tablets such as thickness, hardness, weight variation, friability. The optimized formulation F5 contains the average thickness of 3.12 average hardness of 4.20, average weight variation of 249, and friability of 0.22. The prepared dry mixer for sustained release tablets were also maintained the physiochemical properties of tablets such as thickness, hardness, weight variation, friability. The optimized formulation F3 contains the average thickness of 6.45average hardness of 7.6, friability of 0.39. The F3 formulation which releases the Metformin in sustained manner in up to 12 hours and telmisartan immediate release F5 formulation showed 100.6% drug release with in 30min.