Main Article Content
Abstract
In the present work “Formulation and Evaluation of tramadol Extended Release Tablets” was undertaken. Wet granulation method was formulated. Granules were evaluated for tests such as bulk density, Tapped density, Compressibility Index and Hausner ratio before being punched as tablets. Tablets were tested for weight variation, thickness and friability, in-vitro dissolution tests were performed and percentage drug release was calculated. Dissolution tests were performed and percentage drug release was calculated. Dissolution profile of Formulation – F6 was optimized based on evaluation parameters. In the dissolution modeling all the developed formulations followed Korsemeyer-peppas drug release. The optimized formulation F6 followed Korsemeyer-peppas drug release drug release and non-Fickian model. The developed formulation was tested for its stability for three months and found to be stable.