Main Article Content
Abstract
The main objective of the present study was to enhance a transdermal penetration of a water-insoluble anti-fungal drug, Celecoxib, by encapsulating it into aEthozomalgle. The Ethozomalgle of Celecoxib was prepared firstly by preparing transfersomes by modified hand shaking method using surfactants (Tween 80 and Span 80), Lecithin in various concentrations and chloroform and methanol added in 3:1 ratio in each formulation and evaluated for their vesicle shape and size, entrapment efficiency, % drug content and %entrapment efficiency and in vitro permeation studies. Later carbopol gels such as carbopol 940 along with distilled water was used in the aqueous dispersion of Ethozomes to prepare topical Ethozomalgle. The characterization was carried out and in vitro permeation studies carried out. The results were obtained which showed that Ethozomalgle was a promising candidate for transdermal delivery with targeted and prolonged release of a drug. It also enhances skin permeation of many drugs.