Main Article Content
Abstract
The main aim of this study is to formulate and evaluate Rosiglitazone Nanosuspension. Nanosuspensions are colloidal dispersion of nanosized drug particles stabilized by surfactants. They can also be defined as a biphasic system consisting of pure drug particles dispersed in an aqueous vehicle in which the diameter of the suspended particle is less than 1micro meter in size. Rosiglitazone is an oral rapid and short –acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation sulfonylurea, which means that it undergoes enterohepatic circulation. Rosiglitazone Nanosuspension was prepared by precipitation technique. After preparation of Nanosuspension various characterisation studies were done such as drug content, % yield, FTIR, DSC, TEM, and Invitrodrug release.PVPK30, polaxomer are used as stabilizers. From the dissolution study F4 formulation which containts PVPK30 as stabilizer was considered as optimized formulation. It showed maximum drug release at 30min.FTIR and DSC studies revealed that good stability in dispersion.