Synthesis anti-bacterial and anti-fungal activity of curcumin and its derivatives

Abstract

Three curcumin derivatives having modification in active methylene group (1,3) and keto groups (2) where successfully synthesized. Derivative-1 synthesized from curcumin with 2-hydroxy benzaldehyde using EDTA and Chloroform. Derivative-2 synthesized from curcumin with 4-aminophenol using pyridine and ethanol. Derivative-3 synthesized from curcumin with N,N-dimethylaminobenzaldehyde using EDTA and chloroform. The substitution on the active methylene site of curcumin increases the anti-bacterial and anti- fungal behaviour. While comparing compound 2 which have more potent bacterial activity with compound-1 and compound-3, the former shows higher scavenging activity. Finally the yield was found to be 63%.