Evaluation of novel heterocyclic compounds containing pyrimidine and thiazolidinone rings

Abstract

A new class of heterocyclic compounds containing pyrimidine and thiazolidinone rings was screened for antidiabetic, anti-inflammatory and antioxidant activity by alpha-amylase inhibition, inhibition of protein denaturation and hydrogen peroxide radical scavenging activity respectively by using in vitro method. CompoundsE₁, E_3, E₆, E_7, E_11, and E₁₂have shown promising anti-diabetic activity. CompoundsE₂, E_4, E₆, and E₁₀have shown promising anti-inflammatory activity at 600 µg/ML. concentration. CompoundsE₁, E_6, E_8, E ₉ and E₁₁have shown promising antioxidant activity at 250 µg/ml.