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Abstract
Castleman disease is a rare disease, the reason for the induction of this disease is unknown but as per the lab investigations data, it was found that in patients who are suffering from this disease has shown rise in the levels of the IL-6, CD levels and some other cells which are important for growth. It has been divided into types based on the impact area and intensity of the damage. Lymphadenopathy is the main symptom of this disease. Actually, Interleukin-6 is a multifunctional cytokine that is critical for T/B-cell differentiation and maturation, immunoglobulin secretion, acute-phase protein production, and macrophage/monocyte functions. Signaling of IL-6 cytokine plays an important role in the formation of the Castleman disease, it can be activated with the help of the IL-6 and gp130. Anti IL-6 agents play a major role in the inhibition by blocking the key regions that favor for the disease.