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Abstract
Topical application of drug prevents several drug interactions and lozenge is a better delivery system as the effective concentration of drug can be maintained in the oral cavity for a more prolonged period of time. The aim of study was to develop and evaluate fluconazole lozenges for topical therapy of oropharyngeal candidiasis. The current investigation was designed to improve patient compliance and its efficacy by delivering anti-fungal drug in the form of lozenges. Fluconazole is having poor flowing property it was decided to go for wet granulation in order to increase its ability to flow. For the formulation of compressed tablets lozenges guar gum, tragacanth and HPMC E-5 was used as drug release polymer. Other excipients used were gelatin 6% solution (as binder), sucrose (taste masking agent), methyl paraben (as preservative) and Magnesium stearate (lubricating agent). Among all the formulations F8 showed 98.33 % drug release at 35 min, thickness 4.0±0.1mm, hardness 3.3±0.3 kg/cm3, Friability 0.72±0.26%. F8 batch showed better drug release than other batches, hence F8 was the optimized batch from all formulations.