Main Article Content
Abstract
Conventional oral dosage forms have significant setbacks of poor bioavailability due to hepatic first pass metabolism, drug degradation and sever adverse effects are reported. To improve such character’s transdermal drug delivery system (TDDS) was emerged, which will improve the therapeutic efficacy and safety of drugs by specific sites within the body, thereby reducing both the size and number of doses. Nimusulide is Non-steroidal Anti Inflammatory Drug (NSAID) with analgesic and antipyretic properties. It is used in the treatment of acute pain, the symptomatic treatment of osteoarthritis .It works by blocking the production of prostaglandins (a chemical associated with pain) thereby relieving pain and inflammation. But it is a poorly water-soluble drug. When compared to oral dosage forms, transdermal form of poorly water-soluble drug may act fast. This consideration is the basis for designing the transdermal drug delivery system. In present study Nimusulide patches were prepared by solvent casting method with the combination of hydrophobic polymer (Ethyl Cellulose) and hydrophilic polymer (Poly vinyl pyrollidine) polymers in different ratios without enhancer and with enhancer Di methyl sulphoxide (DMSO).the formulation is evaluated for various physicochemical parameters. Combination of a hydrophilic and hydrophobic polymer can be effectively used to modify and control the release of the drug. The formulation F4 containing PVP: EC (1:2) with Penetration enhancer increases the drug release.