Development of bilayer tablets using processed egg shell for sustained release indomethacine as immediate release component

Abstract

In this present study, it has been carried out to develop the Bilayer tablets of Processed eggshell powder as sustained release and Indomethacin as immediate release component. The prepared formulation satisfied both pre compression and post compression parameters. The compatibility studies were done by using FT-IR. Various sustained release formulations were formulated with HPMC K4M, K15M, K100M, polymer alone; and microcrystalline cellulose was used as diluents. The drug release data of dissolution studies of formulation f4 containing HPMC K100M is shown concentration levels were found to be 98.47% respectively.