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Floating drug delivery offers several applications for drugs having poor bioavailability because of the narrow absorption window in the upper part of the GIT. It retains the dosage form at the site of absorption and thus enhances the bioavailability. The aim of the present study was to design and evaluate bilayer Floating tablets of Metronidazole and Rantidine. An attempt was made to develop bi-layer tablet suitable for delivering different drugs with different release pattern like one layer of drug as immediate release to get quick relief and second drug as sustained release of drug which gives effect of drug for sufficient long time and reduce frequency of dose. The Bilayered tablets containing Rantidine and metronidazole were successfully prepared by direct compression method respectively.


Bi-layered floating tablets Bioavailability Metronidazole and Rantidine

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