Formulation and evaluation of atazanavirsulphate floating matrix tablets

Abstract

AtazanavirSulphate is a highly selective inhibitor of HIV protease and the 7^th protease inhibitor for HIV treatment is formulated as floating matrix tablets, sustained its release for a period of more than 12 hours. AtazanavirSulphate formulated using three different grades of HPMC polymer such as K4M, 15M, and K100M for retardation and sodium bicarbonate for tablet to remain buoyant for duration of release. A total of 18 formulations were prepared changing concentration of polymers and sodium bicarbonate. Of all formulations, F4 formulation shows optimized results following zero order kinetics and regression values nearer to 1, best fitted with Korsmeyer-Peppas model.