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Abstract
Isatinis a unique molecule possessing both amide and keto carbonyl groups. Apart from this, it has an active hydrogen atom attached to nitrogen (or oxygen) and an aromatic ring which should substitute at 5- and 7-positions. Derivatives of isatin are known to have cytotoxicity against human carcinoma cell lines. This compound therefore, has a potential to be used as a chemotherapeutic agent against cancer. This study was done to investigate the antioxidant activity of some novel isatin derivatives. All the new isatin derivatives employed in the investigation have been found to have antioxidant activity. All the compounds were tested at 20, 40,60,80,100 µg/ml concentrations and the results were compared with the standard drug (Ascorbic acid) at the same concentrations. Amongst them, none of the compounds were found to be less active than standard of ascorbic acid.