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Abstract
The present study was undertaken to evaluate the analgesic potential of JM15 (Jasminummultiflorum) and JS25 (Jasminumsambac) formulations using the hot plate method in mice. Both formulations were prepared using successive solvent extraction and supercritical fluid extraction (SFE) techniques to enrich bioactive phytoconstituents. Analgesic activity was assessed by measuring latency to nociceptive response and percentage inhibition of pain threshold. Both formulations significantly increased pain threshold compared to the control group (p < 0.001), with JS25 demonstrating superior efficacy comparable to the standard formulation. The results suggest that Jasminum-derived phytochemicals, particularly flavonoids and lactones, may exert central analgesic effects through modulation of nociceptive pathways.