Analysis of the Analgesic Effects of Jasminum Multiflorum and Jasminum Sambac Formulations in Experimental Mice

Authors

  • Pooja M. Deshmukhe Government College of Pharmacy, Karad, Maharashtra 415124, India
  • Saraswati P. shinde Department of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, taluka- Walwa, District- Sangli, Maharashtra 415404, India
  • Sanket S. Shinde Department of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, taluka- Walwa, District- Sangli, Maharashtra 415404, India
  • Atul R. Chopade Department of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, taluka- Walwa, District- Sangli, Maharashtra 415404, India
  • Pramodkumar J. Shirote Bapuji salunkhe institute of pharmacy Miraj Maharashtra, India

Keywords:

Analgesic activity; Jasminummultiflorum; Jasminumsambac.

Abstract

The present study was undertaken to evaluate the analgesic potential of JM15 (Jasminummultiflorum) and JS25 (Jasminumsambac) formulations using the hot plate method in mice. Both formulations were prepared using successive solvent extraction and supercritical fluid extraction (SFE) techniques to enrich bioactive phytoconstituents. Analgesic activity was assessed by measuring latency to nociceptive response and percentage inhibition of pain threshold. Both formulations significantly increased pain threshold compared to the control group (p < 0.001), with JS25 demonstrating superior efficacy comparable to the standard formulation. The results suggest that Jasminum-derived phytochemicals, particularly flavonoids and lactones, may exert central analgesic effects through modulation of nociceptive pathways.

Downloads


  • Fatal error: Uncaught Error: Call to a member function getData() on null in /home/jpcpharm/public_html/cache/t_compile/20ced12b90181983811d6a2d3549ed558a082564^addd65021fadf964339ab08cd1aa93ba59b14e9c_0.app.frontendobjectsarticledet.php:313 Stack trace: #0 /home/jpcpharm/public_html/lib/pkp/lib/vendor/smarty/smarty/libs/sysplugins/smarty_template_resource_base.php(123): content_69f7958f9947a8_17544733(Object(Smarty_Internal_Template)) #1 /home/jpcpharm/public_html/lib/pkp/lib/vendor/smarty/smarty/libs/sysplugins/smarty_template_compiled.php(114): Smarty_Template_Resource_Base->getRenderedTemplateCode(Object(Smarty_Internal_Template)) #2 /home/jpcpharm/public_html/lib/pkp/lib/vendor/smarty/smarty/libs/sysplugins/smarty_internal_template.php(216): Smarty_Template_Compiled->render(Object(Smarty_Internal_Template)) #3 /home/jpcpharm/public_html/lib/pkp/lib/vendor/smarty/smarty/libs/sysplugins/smarty_internal_template.php(385): Smarty_Internal_Template->render() #4 /home/jpcpharm/public_html/cache/t_compile/20ced12b90181983811 in /home/jpcpharm/public_html/cache/t_compile/20ced12b90181983811d6a2d3549ed558a082564^addd65021fadf964339ab08cd1aa93ba59b14e9c_0.app.frontendobjectsarticledet.php on line 313