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Abstract
Psoriasis is a chronic inflammatory skin disease characterized histologically by hyperproliferation and aberrant differentiation of epidermal keratinocytes. A wide range of conventional medical therapies to treat psoriasis is established from topical therapies and systemic medications through phototherapy or combinations of those. However, most of these therapies have a limited efficacy and may cause a number of side effects. Herbal drugs may become an effective treatment for Psoriasis, causing lower cost and less side effects in comparison to other therapies. The novel herbal products or their active constituents could be potentially used for the treatment of Psoriasis. Noisome is one of the Novel Drug Delivery System used as a Topical formulation for skin diseases. It is formed mostly by non-ionic surfactant and cholesterol incorporation as an excipient and its size ranges from 10nm - 100nm. Niosomes have more penetrating capability than the preparations of emulsions. They can improve the therapeutic performance of the drug molecules by protecting the drug from biological environment. Herbal medicines have been used to treat a variety of diseases including skin disorders. Among plant components, water soluble ones including flavonoids, tannins and terpenoids have been reported to have significant therapeutic effects. However, due to their large molecular size and poor lipid solubility, polyphenolic molecules have low bioavailability, are poorly absorbed and are reached at low concentration to sites of action. Therefore, using new drug delivery system like Niosomes would be helpful in topical herbal formulations.