Main Article Content
Abstract
Drug delivery is now entering quite an exciting and challenging era. Targeted drug delivery, known as smart drug delivery focuses on targeting the medicaments by increasing the residence time and the concentration of drug at the target site of the body (organs, cells, tissues) thus improving the efficacy of treatment and reducing the side effects. Various carriers that can be used in this type of delivery are liposomes, nanoshells, erythrosomes and resealed erythrocytes. In this Innovation era, resealed erythrocytes have become the choice of drug delivery system because of its excellent biocompatibility, biodegradability and ability to entrap several molecules. The promising aspect of resealed erythrocytes makes them useful as a drug carrier. Because of its capacity to circulate throughout the body, biocompatibility, zero order release kinetics of medicines, repeatability, and convenience of administration, resealed erythrocyte is becoming more popular. Erythrocytes are biocompatible, biodegradable, and have long rotation half-lives, allowing them to be loaded with a variety of physiologically active composites in a number of chemical and physical forms (hypotonic dilution, hypotonic hemolysis, electro- insertion, ruse by endocytosis, hypoosmotic lysis). The method of isolation involves collection of sample from the interest, then separating the plasma and finally resealing it. Erythrocytes are prepared by using methods like hypotonic dilution, hypotonic dialysis, pre-swelling, osmotic lysis, endocytosis and chemical penetration. The tremendous potential to achieve site specific drug delivery makes them as first choice of drugs in areas like enzyme therapy, cancer, hepatic tumours and antiviral. This review focus on various methods of encapsulated erythrocytes preparation, techniques of drug loading such as electro- encapsulation, chemical perturbation, entrapment by endocytosis etc, mechanism of resealed erythrocyte release and evaluation resealed erythrocytes and highlights its applications with particular stress in areas of cancer, hepatic tumours and enzyme therapy.