Main Article Content
Abstract
The medication's efficacy and safety profile may be enhanced, dosage may be decreased, and the onset of action may be accelerated with oral disintegrating films. Compared to other conventional dose forms, it dissolves more quickly, becomes more stable, and has a longer half-life. Hydrochlorothiazide (HCT) is a antihypertensive medication used for the sublingual route in order to produce fast-dissolving films that dissolves in saliva quickly and without the need for water. HCT oral disintegrating films were designed to improve bioavailability and patient compliance. The impact on the dissolution profile is measured by HCT. The solvent casting method was used to create the HCT oral disintegrating films (ODF) using natural polymer mango peel pectin and water soluble polymer HPMC E15 of various concentration and mannitol as a plasticizer. The results showed that the medicine vanished quickly. ODF formulations are smooth and easy to swallow, and disintegration time of HF8 formulation containing mango peel pectin 4% was 12 sec while HPMC E15 (HF4) disintegrates in 22 sec. As compare to synthetic polymer, natural polymer mango peel pectin showed lesser disintegration time. HF8 releases the entire medicine within 20 minutes. Upon disintegration, no trace or fragment debris was found. Therefore, based on dissolution tests and disintegration time, the HF8 formulation was determined to be the most optimal formulation among all.