Main Article Content
Abstract
Oral dispersible tablets (ODTs) are patient friendly dosage form that rapidly disintegrant or dispersed in mouth without the need of water. In the present investigation eight ODT formulations of mebendazole, an antiretroviral drug, were prepared using different superdisintegrants Oral dispersible tablets (ODTs) are patient friendly dosage form that rapidly disintegrant or dispersed in mouth without the need of water. In the present investigation eight ODT formulations of mebendazole, an antiretroviral drug, were prepared using different superdisintegrants Oral dispersible tablets (ODTs) are a patient-friendly dose form that swiftly disintegrants or disperses in the mouth without the necessity of water. This study involved the preparation of nine orodispersible tablet formulations of mebendazole (MBZ), an antihelminthic medication, utilizing several natural superdisintegrants. The solubility and dissolving rate of the therapeutic molecules used in this study were improved by using starch tartrate, sodium starch glycolate and croscarmellose sodium as super disintegrating agents. The formulations were all made utilizing 16-station rotary tablet punching machine and the direct compression method, with a 7.5 mm punch. The next step was to compress the improved mixture into tablets and test their solubility in a controlled laboratory setting. The combination of formulations exhibited favorable flow characteristics, including depth of repose, tapped density, and bulk density. The produced tablets passed all quality control assessment criteria according to I.P. limits and demonstrated good post-compression parameters. Formulation MT3 was determined to be the most effective since it released the most medicine (101.28 percent) in the shortest duration of time (15 minutes) and disintegrated within 30.51 seconds. With a dosage of 37.5 mg, the MT3 formulation includes starch tartrate (ST) as a super disintegrant.