Main Article Content
Abstract
The medication's efficacy and safety profile may be enhanced, dosage may be decreased, and the onset of action may be accelerated with oral disintegrating films. Compared to other conventional dose forms, it dissolves more quickly, remains more stable, and has a longer half-life. Dexlansoprazole (DXP) was used for the sublingual route in order to produce fast-dissolving films that dissolves in saliva quickly and without the need for water. DXP ODFs were designed to improve bioavailability and patient compliance. In order to assist the aged, bedridden, and mentally ill, the recipes were developed. The influence on the dissolution profile is measured using DXP. The solvent casting method was used to create the oral disintegrating films (ODFs), which contained PEG 400 as an active ingredient and plasticiser along with natural polymers including guar gum and chitosan in different proportions. The results showed that the medicine vanished quickly. According to this study, DXP might be administered orally using an oral disintegrating film. ODF formulations release all of the drug in 20 minutes after dissolving smoothly and readily. There was no particle matter or residue left after disintegration. It was found that the solvent casting technique worked well for creating the rapidly dissolving DXP films. Oral disintegrating films (ODF) have been used successfully with patients who are immobile, schizophrenic, or travelling when there is no access to water. Prepared films showed a faster start of action and a higher rate of dissolution, which resulted in better patient compliance, effective treatment, and future use growth.