Methodology Development To Synthesis, Characterisation Of Flavone Derivatives And Their Anticancer Activity

Abstract

Flavone derivatives have garnered significant interest in medicinal chemistry due to their promising anticancer properties. This study focuses on the development of an efficient and reproducible methodology for the synthesis and characterization of flavone derivatives. A systematic approach was employed, integrating modern synthetic techniques to achieve high yield and purity of the derivatives. Comprehensive characterization was performed using spectroscopic methods, including NMR, FTIR, and Mass Spectrometry, to confirm structural integrity and molecular composition. The anticancer activity of the synthesized compounds was evaluated through in vitro cytotoxicity assays on various cancer cell lines, highlighting their potential as chemotherapeutic agents. Notable findings include specific derivatives exhibiting significant cytotoxicity with IC50 values comparable to standard anticancer drugs. The structure-activity relationship (SAR) analysis revealed key functional groups contributing to enhanced efficacy. This research lays the groundwork for future studies on flavone derivatives as novel anticancer agents and their translation into clinical applications.