Main Article Content
Abstract
Eprosartan is an antihistamine agent used for the symptomatic relief of seasonal allergic rhinitis such as sneezing, rhinorrhea, pruritus, lacrimation, and nasal congestion. The aim of present research is to develop Eprosartan gelispheres by using ionic gelation method. Eprosartan gelispheres were prepared using different ratios of polymers with alone and combination like HPMC K15M, Ethyl cellulose and carbapol as 1:1, 1:1.5, 1:2 Eprosartan gelispheres were evaluated for percentage yield, particle size. Surface morphology, flow properties, drug content and entrapment efficiency and were found to be within the acceptable range. Invitro dissolution studies of the gelispheres revealed that the formulation F9 containing drug and polymer ratio of Drug: carbapol, in 1:2. shows maximum drug release at the end of 12 hours, when compared with the other formulations. Drug release kinetics of the optimized formulation states that the formulation F9 follows zero order drug release with fickian diffusion mechanism.