Main Article Content
Abstract
The aim of the present study is to develop and evaluate the immediate release tablet of Topiramate by direct compression method. The super disintegrant Khaya gum, Kyron T-314 and Poloxomer 188were used for immediate release of drug from tablet. The precompression blends of Topiramate were characterized with respect to angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio. The precompression blend of all the batches indicates good to fair flowability, compressibility and were compressed into tablets. The formulated tablets were evaluated for various quality control parameters. The pure drug and super disintegrant formulations were subjected to FTIR studies, the results were showed that there is no interaction between the drug and excipients. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F3 exhibits highest dissolution using Kyron T-314 showed faster drug release 98.51%.