Formulation and evaluation of oral controlled release tablets Of nifedipine

Abstract

The aim of the present study was to develop controlled release formulation of Nifedipine to maintain constant therapeutic levels of the drug for over 12 hrs.  Karaya gum, Acacia and Tragacanth were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. From the dissolution studies it was evident that the formulation (F4) showed better and desired drug release pattern i.e., 98.14 % in 12 hours. It contains the Acacia polymer. It followed Zero order release kinetics mechanism.