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From the above experimental results it can be concluded that, Formulated tablets gave satisfactory results for various physicochemical parameters like hardness, friability, thickness, weight variation and content uniformity. HPMC and Ethyl cellulose has predominant effect on the lag time, while also shows significant effect on drug release. Zafirlukast Press coated tablet shows a delayed release pattern.  Among all the core tablet formulation F8 was selected based on drug release within a given period of time.  In-vitro release rate studies showed that the maximum drug release was observed in P3F8 formulations was optimized based on less amount of drug release during lag time. FT-IR studies revealed that there was no interaction between Zafirlukast and the polymers.


Zafirlukast Controlled drug delivery system Press- coated tablets

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