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Abstract
In order to develop a newer or improved analytical method, the analyst has to set some goals. The method should be precise to the drug under study. It is necessary to determine the analyte at trace levels accurately.The UPLC techniques have now become extremely reliable and indispensable.Sitagliptin works to competitively inhibit the enzymedipeptidyl peptidase 4 (DPP-4).Ertugliflozin is a small inhibitor of the SGLT2 and its activity increases glucose excretion, reducing hyperglycemia without the requirement of excessive insulin secretion.The percent recovery of Sitagliptin and Ertugliflozinwas found to be in between 98.0 to 102.0%. The analytical method was found to be linear over the range 25-150 µg/mL of Sitagliptin and 3.75-22.5 µg/mL Ertugliflozinof the target concentration.