Main Article Content
Abstract
In the present work, bioadhesive microspheres of Lornoxicam using Sodium alginate along with Carbopol 934 and Span 80 as copolymers were formulated to deliver Lornoxicam via oral route. The results of this investigation indicate that Ionotropic gelation method can be successfully employed to fabricate Lornoxicam microspheres than emulsion cross linking method. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymer used. Micromeritic studies revealed that the mean particle size of the prepared microspheres was in the size range 548-612µm for ionotropic gelation method and 625-648 µm for emulsion cross linking method,size of ionotropic gelation have high mean partice size than emulsion cross link method and are suitable for bioadhesive microspheres for oral administration. Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size, % swelling and % Mucoadhesion. The in-vitro mucoadhesive study demonstrated that microspheres of Lornoxicam using Span80 as polymer and glutaraldehyde as cross linking agent adhered to the mucus to a greater extent than sodium alginate along with Carbopol934. The invitro drug release decreased with increase in the polymer and copolymer concentration.T3 of Ionotropic gelation method was optimized based on optimum swelling index, percentage mucoadhesion , drug entrapment and drug relaese.The kinetic data analysis of drug release mechanism showed that the drug release from the formulations followed non-Fickian diffusion and the best fit model was found to be Krosmeyer-Peppas.Based on the results of evaluation tests formulation coded T3 was concluded as best formulation.