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Abstract
Nanosponges are nano sized particles designed to look like red blood cell and protect the body. Nanoparticles have been used for unknown preventative measures, such as silverware and wound care products. Silverware contains small silver nanoparticles which contain an antimicrobial agent. The recent advance in nanotechnology has lead to the development of targeted drug delivery system. However, targeting a molecule to a particular site using a drug delivery system effectively requires a specialized drug delivery system. The discovery of nanosponge has become a significant step in overcoming certain problems such as drug toxicity, poor bioavailability and release of drug in a predictable fashion as they can accommodate both hydrophilic and hydrophobic drug. Nanosponges exhibit a porous structure in nature which has the unique ability to entrap the drug moieties and offers a merit of desire release. Nanosponges are tiny sponges that can circulate in the body to reach the specific site and binds on the surface to release the drug in a controlled and predictable manner. Nanosponges can be formulated by crosslinking of cyclodextrine [1] with carbonyl or di-carboxylate (Crosslinkers). Nano sponge’s technology [8] has been explored widely for the delivery of drugs for oral administration, topical administration [6], and parental administration. Nanosponges can also serve as an effective carrier for enzyme, proteins, vaccine and antibodies. The Nanosponge was prepared by solvent evaporation method using polymethyl methacrylate, Ethyl cellulose, and pluronic F127 as rate retarding polymers and PVA as co polymer using ethanol as a solvent