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In the present study the Olmesartan Medoxomil is a selective ACE-II blocking agent which is used in the treatment of hypertension. In this study Olmesartan Medoxomil tablets were prepared by usin fromg different polymers like HPMCK4M, HPMCK15M, HPMCK100M and CARBOPOL and HPC.
15 formulations of floating tablets of Olmesartan Medoxomil were developed by direct compression technique. The F9 formulation was found to be best of all the trials showing that the drug release matches with the brand product.
The best formulation F9 can successfully be employed as a controlled release floating drug delivery system. The floating tablets can control the fluctuations in the plasma drug concentration, increase the gastric residence time and eventually improve the bioavailability of the drug