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As far as the transdermal drug delivery is concern, various penetration enhancers are used for the drug diffusion through skin. In matrix dispersion type systems, the drug is dispersed in the solvent along with the polymers and solvent allowed to evaporate forming a homogeneous drug-polymer matrix.Matrix type systems were developed in the present research. an attempt has been made to develop a matrix-type transdermal therapeutic system comprising of Atenolol with different concentration of various polymers alone using solvent evaporation technique. The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy. The results obtained showed no physical-chemical incompatibility between the drug and the polymers. F1formulation has been selected as the best formulation among all the other formulations. The in vitro drug diffusion studies from the formulation were found to be sustained release. All the evaluation parameters obtained from the best formulation were found to be satisfactory. The data obtained from the in vitro release studies were fitted to various kinetic models like zero order, first order, Higuchi model and peppas model. From the kinetic data it was found that drug release follows peppas modelrelease by diffusion technique from the polymer.


Transdermal drug delivery ethyl cellulose Atenolol solvent evaporation Technique

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