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Abstract
Stiff Person Syndrome (SPS) is a rare, progressive neurological disorder primarily characterized by muscle stiffness, spasms, and functional impairment. Although its precise etiology is unclear, it is often associated with autoimmune responses, frequently observed with elevated anti-glutamic acid decarboxylase (GAD) antibodies. SPS predominantly affects individuals between 30 and 60 years, with a higher incidence in women. Diagnosis is complex, often involving clinical evaluation, blood tests for anti-GAD antibodies, Electromyography (EMG), and MRI scans to exclude other conditions. Treatment approaches are multidimensional, encompassing medication, immunotherapy, physical therapy, and psychotherapy to manage symptoms and improve the patient's quality of life. The prognosis of SPS is variable, and while it may significantly impact the individual's daily living, early diagnosis and appropriate treatment can enhance the patient’s life quality. Continuous research and patient support systems are vital for individuals living with SPS. For personalized medical advice, consulting healthcare professionals is recommended.