Formulation development and in vitro characterization of flurbiprofen sustained release matrix tablets

Abstract

In the present work, an attempt has been made to develop Sustained release tablets of Flurbiprofen by selecting natural polymers Tragacanth, Acacia gum, and Xanthan gum as retarding polymers. All the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F2 formulation showed maximum % drug release i.e., 95.19% in 12 hours  hence it is considered as optimized formulation F2 which contains Tragacanth (100 mg). Optimized formulation F2 was followed Higuchi release kinetics mechanism.