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Cardiovascular diseases are the biggest killers in the world according to WHO, of which stroke and ischemic heart disease are main diseases, which nearly cause 15 million deaths. Drug Related Problems are defined as a circumstance or an event which involves the pharmacotherapy or the drug treatment that interferes with the optimum outcome of medical care of a patient. DRP’S are classified into 4 categories according to PCNE classification V.5.01 which are the Problems, Causes, Interventions and the Outcome of intervention. The main aim of the study is to detect the drug related problems among the patients with cardiovascular diseases admitted to the hospital in a tertiary Rohini hospital. A cross sectional observational study with a sample size of 100 patients in a period of 6 months was included as per inclusion criteria and exclusion criteria. All the case record sheets of patients above 18 years are collected to assess the drug related problems. Of all the 100 case records collected,44 DRP’S were found in 39 patients. The major DRP identified is Drug interactions-26 followed by ADR’S-15, Therapeutic duplication-2 and Wrong dose-1. Mainly the 33 DRP’S were found in 29 male patients with an incidence rate of 41.4% when compared to females,11 DRP’S in 10 patients with an incidence rate of 33.3%. The drug related problems have higher incidence rate in male patients than in female patients. Most common drug related problems observed are Drug Interactions followed by the Adverse Drug Reactions. Interventions are generally made at the prescriber level and the outcome of intervention in most of the cases is totally solved.