Main Article Content
Abstract
Mucoadhesive tablets of Piroxicam were prepared by using Tragacanth, Xanthan gum and Tamarind Gum as mucoadhesive polymers. Nine formulations were developed with varying concentrations of polymers. F1 to F9 formulations were composed of Tragacanth, Xanthan gum and Tamarind Gum in ratios of 1:1, 1:2 and 1:3. The formulated mucoadhesive buccal tablets were assessed for quality attributes like weight variation, hardness, thickness, friability, drug content, moisture absorption, surface pH and in vitro drug release studies. Optimized formulation G4 showed maximum release of the drug (99.61%). The FTIR results showed no evidence of interaction between the drug and polymers. All the evaluation parameters given the positive result and comply with the standards. The results indicated that the mucoadhesive buccal tablets of Piroxicam may be good choice to bypass the extensive hepatic first pass metabolism with an improvement in bioavailability of Piroxicam through buccal mucosa.