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Angiotensin II receptor blockers, the first novel type of antihypertensive medication, includes losartan potassium. High blood pressure, commonly known as hypertension, is a disorder that develops when the blood pressure is too high. The smaller blood arteries (the arterioles) constrict, which causes increased blood pressure against the artery walls and makes the heart work harder to maintain blood pressure. This condition is known as hypertension. The tablet-based medication has been marketed as "the antihypertensive for the '90s and beyond" with a reduced incidence of adverse effects than (is) typically associated with other antihypertensives. The analytical methods Based on previously published articles from a variety of journals, this study includes UV spectroscopy, Reverse phase-high performance liquid chromatography (RP-HPLC), High performance thin layer chromatography (HPTLC), Liquid chromatography/mass spectrometry (LC/MS), and Ultra performance liquid chromatography mass spectrometry(UPLCMS).