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The present research work deals with the development, optimization and validation of RP-HPLC method for the simultaneous estimation of Telmisartan and Hydrochlorothiazide in combined dosage form. Market is folded with combination of drugs in various dosage forms. The multi-component formulations have gained a lot of importance now days due to greater patient acceptability, increased potency, multiple action, fewer side effects and quicker reliefs. For simultaneous estimation of drugs present in multi-component dosage form, High Pressure Liquid Chromatography (HPLC) is considered to be most suitable since it is extremely precise, accurate, sensitive, linear and rapid. So the objective of the present work is to develop HPLC method for simultaneous estimation of drugs in combined dosage form for which no better analytical method has been previously reported. The Method employs Waters HPLC system on XTerra, Symmetry C18 (4.6 x 150mm, 5mm) Column. The flow rate was 1.0ml/min and the detection was carried out at 274 nm. Selected mobile phase was a combination of Methanol: Buffer (Potassium dihydrogen phosphate) in the ratio of 70:30 and PH 2.5 (adjusted with Orthophosphoric acid).The Retention times of Hydrochlorothiazide and Telmisartan were found to be 1.723 and 3.769 minutes respectively. Linearity ranges for Hydrochlorothiazide and Telmisartan were 6.25 - 31.25ppm and 20-100ppm respectively. The correlation co-efficient of Telmisartan and Hydrochlorothiazide was found to be 0.999. Percent recovery was found to be within the range of 98.0 % to 102.0%.Theproposed method was found to be precise, selective, rapid and economical. It can be successfully utilized for the simultaneous determination of Telmisartan and Hydrochlorothiazide in pharmaceutical dosage form.