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The purpose of this research was to formulate and evaluate the Floating sustained release tablets of Perindopril 4mg, Perindopril is a medication used to treat high blood pressure, heart failure, or stable coronary artery disease. The floating tablets were based on effervescent approach using sodium bicarbonate a gas generating agent. All formulations were evaluated for the pre compression and post compression, In vitro buoyancy, In vitro dissolution studies. Pre-compression studies revealed that there was no sign of any interaction between drug and polymers and all formulation showed good flow properties. Results of post compression parameters were found within the limits for all formulations. Among all the formulation F6 showed better buoyancy and drug release profile. The release of drug from the prepared formulations (F6) was found to follow zero order and mechanism


Perindopril, Carbapol 934, HPMC K 100, Eudragit RSPO and Floating tablets.

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